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2-(HydroxyMethyl)butane-1,4-diol, also known as D-mannitol or mannitol, is a sugar alcohol derived from glucose. It is a white, crystalline powder with a sweet taste and possesses various therapeutic benefits.

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  • 6482-32-2 Structure
  • Basic information

    1. Product Name: 2-(hydroxyMethyl)butane-1,4-diol
    2. Synonyms: 2-(hydroxyMethyl)butane-1,4-diol;2-(HydroxyMethyl)-1,4-butanediol
    3. CAS NO:6482-32-2
    4. Molecular Formula: C5H12O3
    5. Molecular Weight: 120.14698
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 6482-32-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 331.3 °C at 760 mmHg
    3. Flash Point: 154.1 °C
    4. Appearance: /
    5. Density: 1.22 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 14.37±0.10(Predicted)
    10. CAS DataBase Reference: 2-(hydroxyMethyl)butane-1,4-diol(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-(hydroxyMethyl)butane-1,4-diol(6482-32-2)
    12. EPA Substance Registry System: 2-(hydroxyMethyl)butane-1,4-diol(6482-32-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6482-32-2(Hazardous Substances Data)

6482-32-2 Usage

Uses

Used in Food and Beverage Industry:
2-(HydroxyMethyl)butane-1,4-diol is used as a sweetening agent for its sweet taste, enhancing the flavor of various food and beverage products.
Used in Pharmaceutical Formulations:
2-(HydroxyMethyl)butane-1,4-diol is used as an excipient to improve the stability and shelf life of medications, ensuring the quality and effectiveness of pharmaceutical products.
Used in Ophthalmology:
2-(HydroxyMethyl)butane-1,4-diol is used as a medication to reduce pressure inside the eyes, helping to treat glaucoma and other eye conditions.
Used in Nephrology:
2-(HydroxyMethyl)butane-1,4-diol is used to treat certain kidney conditions, supporting kidney function and overall health.
Used as a Diuretic:
2-(HydroxyMethyl)butane-1,4-diol is used to increase urine production, promoting the removal of excess water and salts from the body and aiding in the management of fluid balance.

Check Digit Verification of cas no

The CAS Registry Mumber 6482-32-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,8 and 2 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 6482-32:
(6*6)+(5*4)+(4*8)+(3*2)+(2*3)+(1*2)=102
102 % 10 = 2
So 6482-32-2 is a valid CAS Registry Number.

6482-32-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Hydroxymethyl)-1,4-butanediol

1.2 Other means of identification

Product number -
Other names 2 - (Hydroxymethyl) - 1,4 - butanediol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6482-32-2 SDS

6482-32-2Relevant articles and documents

NANOMATERIALS

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Paragraph 0320; 0321; 0322, (2021/07/17)

Lipid nanoparticle compositions for delivery of nucleic acids are described. In various embodiments the lipid nanoparticle contains an ionizable lipid of the Formula (I). Methods of using such lipid nanoparticle compositions to achieve targeted delivery of therapeutic cargo without the need for a targeting ligand are also provided.

NANOMATERIALS

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Paragraph 0436-0438, (2021/06/11)

Lipid nanoparticle compositions for delivery of nucleic acids are described. The lipid nanoparticle may contain a conformationally constrained ionizable lipid as part of the composition. These compositions may allow for delivery of cargo without the need for a targeting ligand.

FLAME RETARDANT ITACONIC ACID-BASED COMPOUNDS

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Paragraph 0053, (2019/04/25)

A flame retardant itaconic acid-based compound, a process for forming a flame retardant polymer, and an article of manufacture comprising a material that contains a flame retardant itaconic acid-based polymer are disclosed. The flame retardant itaconic acid-based compound has variable moieties, which include methylene bridge groups, carbonyl groups, vinyl groups, functionalized groups, phenyl-substituted flame retardant groups, and/or functionalized flame retardant groups. The process for forming the flame retardant polymer includes forming a phosphorus-based flame retardant molecule, forming an itaconic acid derivative, chemically reacting the phosphorus-based flame retardant molecule and the itaconic acid derivative to form a flame retardant itaconic acid-based compound, and incorporating the itaconic acid-based flame retardant compound into a polymer to form the flame retardant polymer.

Insecticide dinotefuran intermediate 3 - hydroxy methyl tetrahydrofuran synthetic method

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Paragraph 0029; 0048; 0049, (2018/04/01)

The invention discloses a synthetic method of pesticide dinotefuran intermediate 3-hydroxymethyl tetrahydrofuran, and the synthetic method is as follows: reacting compound succinic acid dialkyl ester with formic acid alkyl ester in the presence of a strong alkali to obtain a compound III, then obtaining a compound II by a reduction reaction, finally, in the presence of an acid catalyst, obtaining a compound shown as formula I by a dehydration cyclization reaction, and R or R ' respectively independently represents C1-5 alkyl. The synthetic method is low in raw material cost, simple in reaction operation, less in pollution, high in yield of each step, 99% in the yield of the reducing step, and suitable for industrial production.

Method for synthesizing 3-tetrahydrofurfuryl alcohol

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Paragraph 0007; 0022, (2017/01/17)

The invention relates to a method for synthesizing 3-tetrahydrofurfuryl alcohol. According to the technical scheme, 2-bromoethanol and diethyl malonate serve as starting materials, under the alkaline condition, 2-hydroxyethyl-diethyl malonate is generated through a reaction, hydrolysis is conducted on the 2-hydroxyethyl-diethyl malonate to generate 2-hydroxyethyl-malonate, catalyzing and high-pressure hydrotreatment are conducted on the 2-hydroxyethyl-malonate to generate 2-hydroxymethyl-1,4-butanediol, and dehydration cyclization is conducted on the 2-hydroxyethyl-1,4-butanediol to generate the 3-tetrahydrofurfuryl alcohol. According to the method for synthesizing the 3-tetrahydrofurfuryl alcohol, the yield can reach over 85 percent, the purity can reach above 95 percent, the reaction condition is mild, the cost is low, operation is easy, and the method has the advantage of being suitable for industrial production.

A 3-hydroxy methyl tetrahydrofuran method for the synthesis of

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Paragraph 0020, (2017/03/08)

The invention discloses a synthetic method for 3-hydroxylmethal tetrahydrofuran. The synthetic method comprises the following steps: with 2-chloroethanol and diethyl malonate as raw materials, reacting under the action of alkaline in the presence of an organic solvent or in absence of a solvent to obtain an intermediate 2-ethoxy-diethyl succinate; then, reducing the intermediate 2-ethoxy-diethyl succinate by virtue of metal borohydride to obtain 2-hydroxymethyl-1,4-butanediol; and finally, producing 3-hydroxylmethal tetrahydrofuran under the action of a dehydrating agent. According to the synthetic method, the usage amount of the reducing agent metal borohydride is remarkably lowered, and yield of a byproduct sodium metaborate is reduced at the same time. The invention provides the synthetic method for the drug intermediate 3-hydroxylmethal tetrahydrofuran.

Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents

You, Hyun,Youn, Hyung-Seop,Im, Isak,Bae, Man-Ho,Lee, Sang-Kook,Ko, Hyojin,Eom, Soo Hyun,Kim, Yong-Chul

experimental part, p. 1153 - 1164 (2011/04/17)

NAmPRTase (PBEF/Visfatin) plays a pivotal role in the salvage pathway of NAD+ biosynthesis. NAmPRTase has been an attractive target for anti-cancer agents that induce apoptosis of tumor cells via a declining plasma NAD+ level. In this report, a series of structural analogs of FK866 (1), a known NAmPRTase inhibitor, was synthesized and tested for inhibitory activities against the proliferation of cancer cells and human NAmPRTase. Among them, compound 7 showed similar anti-cancer and enzyme inhibitory activities to compound 1. Further investigation of compound 7 with X-ray analysis revealed a co-crystal structure in complex with human NAmPRTase, suggesting that Asp219 in the active site of the enzyme could contribute to an additional interaction with the pyrrole nitrogen of compound 7.

Novel isopentenyladenosine analogues: Synthesis, characterization, and evaluation of antiproliferative activity on bladder carcinoma cells

Ottria, Roberta,Casati, Silvana,Maier, Jeanette A. M.,Mariotti, Massimo,Ciuffreda, Pierangela

experimental part, p. 736 - 751 (2010/09/04)

Isopentenyladenosine (iPA), a member of the cytokinin family of plant hormones, exerts a marked antiproliferative activity on some leukemic and epithelial cancer cell lines. To characterize the molecular moieties required for the in vitro antitumor activity of the molecule and to obtain cytostatic iPA derivatives potentially useful as chemotherapeutic agents, N9-acyclic analogues have been synthesized using regioselective Mitsunobu reaction and characterized by elemental analyses, 1H and 13C NMR. These compounds were analyzed for their activity on human bladder cancer cell lines. In this study, we report that iPA inhibited the proliferation but not the migration of human bladder cancer cells, while the newly synthesized analogues revealed no significant cytostatic activity apart from the compound with a saturated double bond of the isopentenyl chain. These results indicate that the integrity of the ribose ring is required for the cytostatic activity of iPA.

PREVENTION AND TREATMENT OF CANCER AND OTHER DISEASES

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Page/Page column 68, (2008/06/13)

Nucleoside chemical compounds, which interact with specific structures of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) are disclosed. The compounds interfere with the activities of telomerase and reverse transcriptase, and are useful as antivirals, antibacterials and anticancer agents. Methods of treating or preventing cancers in patients involving administration of a therapeutically effective amount of a composition having an inhibitor or antagonist of the reverse transcriptases (RTs) expressed in cells of the patients are also disclosed. Method of using nucleoside analogs and other inhibitors of RTs in conjunction with DNA damaging agents such as genotoxic agents or radiation or photodynamic therapy or combinations these for the treatment of various cancers are also disclosed.

DUTPASE INHIBITORS

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Page/Page column 40, (2008/06/13)

Deoxyuridine derivatives of the formula (I) where R1 is H or various substituents; D is -NHCO-, -CONH-, -0-, -C(=O)-, -CH=CH, -CΞC-, -NR5-; R4 is hydrogen or various substituents; R5 is H, C1-C4 alkyl, C1-C4 alkanoyl; E is Si or C; R6, R7 and R8 are independently selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl or a stable monocyclic, bicyclic or tricyclic ring system; G is -O-, -S-, -CHR10-, -C(=O)-; J is -CH2-, or when G is CHR10 may also be -O- or -NH-; R10 is H, F, -CH3, -CH2NH2, -CH2OH; -OH R11 is H, F, -CH3, -CH2 NH2, -CH2OH, CH(OH)CH3, CH(NH3)CH3; or R10 and R11 together define an olefinic bond, or together form a -CH2-group, thereby defining a cis or trans cyclopropyl group; have utility in the prophylaxis or treatment of protozoal diseases such as malaria.

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