N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide

Base Information

• Chemical Name: N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide
• CAS No.: 142741-11-5
• Molecular Formula: C₁₈H₂₁NO₄
• Molecular Weight: 315.369
• Mol file: 142741-11-5.mol

Synonyms:N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide

Chemical Property of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide

There total 1 articles about N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

m-hydroxyphenylacetic acid (621-37-4) + 2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide (142741-11-5)

Guidance literature:

Reference yield:

N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide (142741-11-5) → C18H19NO3

Guidance literature:

With trichlorophosphate; In toluene; at 90 ℃; for 2h;

DOI:10.1021/cn500330v

Reference yield:

N-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-(3-hydroxy-phenyl)-acetamide (142741-11-5) → 1-(3-hydroxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (109250-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / toluene / 2 h / 90 °C

2: sodium tetrahydroborate / methanol / 20 °C / Inert atmosphere; Cooling with ice

With sodium tetrahydroborate; trichlorophosphate; In methanol; toluene; 1: |Bischler-Napieralski Reaction;

DOI:10.1021/cn500330v

upstream raw materials:

m-hydroxyphenylacetic acid

2-(3,4-dimethoxyphenyl)-ethylamine

Downstream raw materials:

1-(3-benzyloxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

1-(3-benzyloxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

3-(6,7-Dimethoxy-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol; hydrochloride

1-(3-hydroxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline