(R)-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide
CAS No.:1194044-26-2
Molecular Formula:C₁₂H₁₅BrFNOS
Molecular Weight:320.226
Hs Code.:
European Community (EC) Number:810-396-4
DSSTox Substance ID:DTXSID101132039

Synonyms:(R)-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide;(NE,R)-N-[1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide;1346145-51-4;1194044-26-2;SCHEMBL569258;SCHEMBL15991220;DTXSID101132039;AS-73579;CS-0059668;[N(E),S(R)]-N-[1-(5-Bromo-2-fluorophenyl)ethylidene]-2-methyl-2-propanesulfinamide

Suppliers and Price of (R)-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (R)-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:319.00418
Heavy Atom Count:17
Complexity:327

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=NS(=O)C(C)(C)C)C1=C(C=CC(=C1)Br)F
Isomeric SMILES:C/C(=N\[S@](=O)C(C)(C)C)/C1=C(C=CC(=C1)Br)F

Technology Process of (R)-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide

There total 4 articles about (R)-N-[(1E)-1-(5-bromo-2-fluorophenyl)ethylidene]-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 196929-78-9
(R)-2-methylpropane-2-sulfinamide

: 1194044-26-2
(R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2-fluoro-phenyl)-ethylidene]-amide

Guidance literature:: With titanium(IV) isopropylate; In tetrahydrofuran; at 80 ℃; for 16h;

Reference yield:

: 93777-26-5
5-bromo-2-fluorobenzaldehyde

: 1194044-26-2
(R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2-fluoro-phenyl)-ethylidene]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 1 h / -78 - -5 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 7 h / Reflux

3: titanium(IV) tetraethanolate / tetrahydrofuran / 4.5 h / Inert atmosphere; Reflux

With titanium(IV) tetraethanolate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 552331-15-4
1-(5-bromo-2-fluorophenyl)ethan-1-ol

: 1194044-26-2
(R)-2-methyl-propane-2-sulfinic acid [1-(5-bromo-2-fluoro-phenyl)-ethylidene]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 7 h / Reflux

2: titanium(IV) tetraethanolate / tetrahydrofuran / 4.5 h / Inert atmosphere; Reflux

With titanium(IV) tetraethanolate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethyl acetate;