10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one

Base Information

• Chemical Name: 10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one
• CAS No.: 1609244-04-3
• Molecular Formula: C₁₉H₁₇NO₂
• Molecular Weight: 291.349
• Mol file: 1609244-04-3.mol

Synonyms:10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one

Chemical Property of 10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one

There total 6 articles about 10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C19H17N3O2 (1609243-95-9) → 10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one (1609244-04-3)

Guidance literature:

With [Rh₂(a,a,a’,a’-tetramethyl-1,3-benzenedipropionic acid)₂]; In toluene; at 130 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201308611

Reference yield: 70.0%

6-((2-iodophenyl)amino)-4'-methoxy-4,5-dihydro-[1,1'-biphenyl]-2(3H)-one → 10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one (1609244-04-3)

Guidance literature:

With potassium phosphate; palladium diacetate; In dimethyl sulfoxide; at 120 ℃; for 2.83333h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b04128

Reference yield:

2-iodophenylamine (615-43-0) → 10-(4-methoxyphenyl)-8,9-dihydropyrido[1,2-a]indol-6(7H)-one (1609244-04-3)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 6 h / Dean-Stark; Reflux; Inert atmosphere

2: palladium diacetate; potassium phosphate / dimethyl sulfoxide / 2.83 h / 120 °C / Sealed tube; Inert atmosphere

With potassium phosphate; palladium diacetate; toluene-4-sulfonic acid; In dimethyl sulfoxide; toluene;

DOI:10.1021/acs.orglett.8b04128

upstream raw materials:

1-((4-methoxyphenyl)ethynyl)cyclobutanol

C₁₉H₁₉NO₂

C₁₉H₁₇N₃O₂

4-methoxyphenylacetylen