1-Benzyl-4-Piperidine acetic acid ethylester

Base Information

• Chemical Name: 1-Benzyl-4-Piperidine acetic acid ethylester
• CAS No.: 71879-59-9
• Molecular Formula: C16H23 N O2
• Molecular Weight: 261.364
• Hs Code.: 2933399090
• Mol file: 71879-59-9.mol

Synonyms:1-(Phenylmethyl)-4-piperidineaceticacid ethyl ester; Ethyl 1-benzyl-4-piperidineacetate

Chemical Property of 1-Benzyl-4-Piperidine acetic acid ethylester

Chemical Property:

• Boiling Point: 342.1±15.0 °C(Predicted)
• PKA: 8.60±0.10(Predicted)
• PSA: 29.54000
• Density: 1.045±0.06 g/cm3(Predicted)
• LogP: 2.78970

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzyl-4-Piperidine acetic acid ethylester

There total 11 articles about 1-Benzyl-4-Piperidine acetic acid ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

ethyl 2-(1-benzylpiperidine-4-ylidene)acetate (40110-55-2) → ethyl (1-benzylpiperidin-4-yl)acetate (71879-59-9)

Guidance literature:

With hydrogen; Lindlar catalyst; In methanol; for 0.833333h;

DOI:10.1016/S0040-4039(97)10666-9

Reference yield: 90.0%

ethyl (piperidin-4-yl)acetate (59184-90-6) + benzyl bromide (100-39-0) → ethyl (1-benzylpiperidin-4-yl)acetate (71879-59-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2016.07.025

Reference yield: 88.0%

ethyl (piperidin-4-yl)acetate (59184-90-6) + benzyl chloride (100-44-7) → ethyl (1-benzylpiperidin-4-yl)acetate (71879-59-9)

Guidance literature:

With potassium carbonate; In acetone; for 22h; Reflux;

DOI:10.1021/jm900722z

upstream raw materials:

ethyl (piperidin-4-yl)acetate

benzyl chloride

1-phenylmethyl-4-piperidone

diethoxyphosphoryl-acetic acid ethyl ester

Downstream raw materials:

1-Benzyl-4-(3,4-dimethoxyphenyethylcarbamoylmethyl)piperidine

N-benzyl-4-(2-hydroxyethyl)piperidine

2-(1-benzylpiperidin-4-yl)acetic acid

1-(1-benzyl-piperidin-4-yl)-3-methyl-butan-2-ol

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