((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol

Base Information

• Chemical Name: ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol
• CAS No.: 242808-65-7
• Molecular Formula: C₁₃H₁₈O₄
• Molecular Weight: 238.284
• Mol file: 242808-65-7.mol

Synonyms:((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol

Chemical Property of ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol

There total 11 articles about ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C13H18O3 (146916-74-7) → ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol (242808-65-7)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; D-(-)-DET; In dichloromethane; at -25 ℃; Molecular sieve;

DOI:10.1039/c0cc00056f

Reference yield: 91.0%

(E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol (158817-21-1) → ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol (242808-65-7)

Guidance literature:

With titanium(IV) isopropylate; 4 A molecular sieve; D-(-)-diisopropyl tartrate; tert.-butylhydroperoxide; In dichloromethane; at -20 ℃; for 12h;

DOI:10.1021/jo070862j

Reference yield: 83.0%

(E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol (158817-21-1) → ((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl) oxiran-2-yl)methanol (146986-42-7) + ((2R,3R)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)methanol (242808-65-7)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; In dichloromethane; at -20 ℃; for 6h; Title compound not separated from byproducts.;

DOI:10.1016/j.tetlet.2007.11.107

upstream raw materials:

methyl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate

(E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol

p-Methoxybenzyl bromide

5-(4-methoxyphenyl)methoxy-2-pentyn-1-ol

Downstream raw materials:

(2S,3R)-2-iodomethyl-3-[2-(4-methoxybenzyloxy)ethyl]oxirane

(2S,3R)-2-Chloromethyl-3-[2-(4-methoxy-benzyloxy)-ethyl]-oxirane

tert-butyl-{1-[2-(4-methoxy-benzyloxy)-ethyl]-prop-2-ynyloxy}-dimethyl-silane

C₃₁H₄₈O₉Si