5-(4-Methoxybenzyloxy)-2-pentene-1-ol

Base Information

• Chemical Name: 5-(4-Methoxybenzyloxy)-2-pentene-1-ol
• CAS No.: 158817-21-1
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• DSSTox Substance ID: DTXSID801243857
• Nikkaji Number: J2.856.444I,J2.069.243J
• Mol file: 158817-21-1.mol

Synonyms:SCHEMBL8064124;DTXSID801243857;5-(4-Methoxybenzyloxy)-2-pentene-1-ol;(e)-5-(4-methoxybenzyloxy)pent-2-en-1-ol;(E)-5-(4-Methoxybenzyloxy)-2-pentene-1-ol;(2E)-5-[(4-Methoxyphenyl)methoxy]-2-penten-1-ol;158817-21-1

Chemical Property of 5-(4-Methoxybenzyloxy)-2-pentene-1-ol

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 222.125594432
• Heavy Atom Count: 16
• Complexity: 184

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)COCCC=CCO
• Isomeric SMILES: COC1=CC=C(C=C1)COCC/C=C/CO

Technology Process of 5-(4-Methoxybenzyloxy)-2-pentene-1-ol

There total 15 articles about 5-(4-Methoxybenzyloxy)-2-pentene-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate (201667-72-3) → (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol (158817-21-1)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 1h;

DOI:10.1016/S0040-4020(97)10253-8

Reference yield: 97.0%

ethyl <2E>-5-(4-methoxybenzyloxy)-2-pentenoate (172427-68-8) → (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol (158817-21-1)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at -78 ℃; for 0.25h;

DOI:10.1016/j.tet.2003.09.070

Reference yield: 91.0%

5-(4-methoxyphenyl)methoxy-2-pentyn-1-ol (146916-76-9) → (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol (158817-21-1)

Guidance literature:

With lithium aluminium tetrahydride; sodium methylate; In tetrahydrofuran; for 5.25h; Heating;

DOI:10.1016/j.tet.2006.02.073

upstream raw materials:

5-(4-methoxyphenyl)methoxy-2-pentyn-1-ol

methyl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate

ethyl <2E>-5-(4-methoxybenzyloxy)-2-pentenoate

p-Methoxybenzyl bromide

Downstream raw materials:

((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl) oxiran-2-yl)methanol

(E)-5-(4-methoxy-benzyloxy)-pent-2-en-1-al

(E)-1-[(tert-butyldiphenylsilyl)oxy-5-(4-methoxybenzyl)oxy]pent-2-ene

(E)-5-(4-methoxybenzyloxy)pent-2-enyl methyl carbonate