(3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

Base Information

Chemical Name:(3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid
CAS No.:1354546-38-5
Molecular Formula:C₁₃H₁₉BO₆S
Molecular Weight:314.167
Hs Code.:

Synonyms:(3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

Suppliers and Price of (3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

There total 3 articles about (3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1354546-85-2
methyl (2R)-2-methyl-2-(methylsulfonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]butanoate

: 1354546-38-5
(3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

Guidance literature:: With hydrogenchloride; sodium periodate; In tetrahydrofuran; water; at 20 ℃; for 16h;
DOI:10.1021/jm2014748

Reference yield:

: 1289626-07-8
ethyl 4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoate

: 1354546-38-5
(3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

1.2: Reflux

2.1: sodium hydrogencarbonate / tetrahydrofuran; water / Reflux

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / Reflux

4.1: hydrogenchloride; sodium periodate / tetrahydrofuran; water / 16 h / 20 °C

With hydrogenchloride; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water;
DOI:10.1021/jm2014748

Reference yield:

: 1289626-32-9
(2R)-4-(4-bromophenyl)-2-methyl-2-(methylsulfonyl)butanoic acid

: 1354546-38-5
(3R)-4-(4-methoxy-3-methyl-3-(methylsulfonyl)-4-oxobutyl)phenylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrahydrofuran; water / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 16 h / Reflux

3: hydrogenchloride; sodium periodate / tetrahydrofuran; water / 16 h / 20 °C

With hydrogenchloride; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/jm2014748