(R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea

Base Information

Chemical Name:(R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea
CAS No.:946588-02-9
Molecular Formula:C₂₃H₃₆ClN₃O₃
Molecular Weight:438.01
Hs Code.:

Synonyms:(R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea

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Chemical Property of (R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea

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Technology Process of (R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea

There total 4 articles about (R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 946593-51-7
(R)-2-amino-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methylbutan-1-one hydrochloric acid salt

: phenyl (R)-sec-butylcarbamate

: 946588-02-9
(R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea

Guidance literature:: With triethylamine; In acetonitrile; at 100 - 150 ℃; for 2h; Microwave irradiation; Inert atmosphere;
DOI:10.1021/jm5003167

Reference yield:

: 946594-20-3
tert-butyl (R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

: 946588-02-9
(R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

2: triethylamine / acetonitrile / 2 h / 100 - 150 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; triethylamine; In 1,4-dioxane; acetonitrile;
DOI:10.1021/jm5003167

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 946588-02-9
(R)-1-sec-butyl-3-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

3: triethylamine / acetonitrile / 2 h / 100 - 150 °C / Microwave irradiation; Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm5003167