(E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

Base Information

Chemical Name:(E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile
CAS No.:1174272-23-1
Molecular Formula:C₁₈H₂₃NOSi
Molecular Weight:297.472
Hs Code.:

Synonyms:(E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

Suppliers and Price of (E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

Chemical Property:

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Technology Process of (E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

There total 1 articles about (E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1011718-03-8
3-tert-butyldimethylsilyl-2-propynenitrile

: 768-60-5
4-methoxyphenylacetylen

: 1174272-23-1
(E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

: 1174272-22-0
(Z)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

Guidance literature:: With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; triphenylborane; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetradecane; toluene; at 40 ℃; for 48h; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2009.03.079

Reference yield: 94.0%

: 1174272-23-1
(E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile

: 1174272-37-7
(E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynal

Guidance literature:: (E)-5-tert-butyldimethylsilyl-2-(4-methoxyphenyl)pent-2-en-4-ynenitrile; With diisobutylaluminium hydride; In toluene; at -78 ℃; for 1h; Inert atmosphere;

With methanol; In toluene; at -78 - 20 ℃; Inert atmosphere;

With silica gel; In hexane; ethyl acetate;
DOI:10.1016/j.tet.2009.03.079