di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate

Base Information

Chemical Name:di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate
CAS No.:1399008-14-0
Molecular Formula:C₂₂H₃₅IN₂O₆
Molecular Weight:550.434
Hs Code.:

Synonyms:di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate

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Chemical Property of di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate

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Technology Process of di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate

There total 3 articles about di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 41046-67-7
2-iodoresorcinol

: 119768-44-4
tert-butyl [(2R)-2-hydroxypropyl]carbamate

: 1399008-14-0
di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate

Guidance literature:: 2-iodoresorcinol; tert-butyl [(2R)-2-hydroxypropyl]carbamate; With triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 0.166667h; Inert atmosphere;

With di-isopropyl azodicarboxylate; In tetrahydrofuran; toluene; at 0 - 26 ℃; for 13.6667h; Inert atmosphere;
DOI:10.15227/orgsyn.098.0001

Reference yield: 83.0%

: 41046-67-7
2-iodoresorcinol

: 167938-56-9
tert-butyl [(2S)-2-hydroxypropyl]carbamate

: 1399008-14-0
di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; at 0 - 25 ℃; for 12h;
DOI:10.1002/anie.201303559

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1399008-14-0
di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.17 h / 0 °C / Inert atmosphere

1.2: 5.33 h / 0 - 26 °C / Inert atmosphere

2.1: triphenylphosphine / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

2.2: 13.67 h / 0 - 26 °C / Inert atmosphere

With triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.15227/orgsyn.098.0001