167938-56-9

Basic information

• Product Name: N-BOC-(S)-1-AMINO-2-PROPANOL
• Synonyms: BOC-(S)-(+)-1-AMINO-2-PROPANOL;BOC-(S)-1-AMINO-2-PROPANOL;N-T-BOC-(S)-1-AMINO-2-PROPANOL;N-BOC-(S)-1-AMINO-2-PROPANOL;Carbamic acid, [(2S)-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI);(S)-1-(Boc-amino)-2-propanol, 97%;(S)-tert-Butyl (2-hydroxypropyl)carbamate;N-Boc-(S)-2-hydroxypropanamine
• CAS NO: 167938-56-9
• Molecular Formula: C₈H₁₇NO₃
• Molecular Weight: 175.23
• Product Categories: N-BOC
• Mol File: 167938-56-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 276.441 °C at 760 mmHg
• Flash Point: 120.988 °C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.45
• Storage Temp.: 2-8°C
• PKA: 12.42±0.46(Predicted)
• CAS DataBase Reference: N-BOC-(S)-1-AMINO-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-(S)-1-AMINO-2-PROPANOL(167938-56-9)
• EPA Substance Registry System: N-BOC-(S)-1-AMINO-2-PROPANOL(167938-56-9)

Safety Data

• Hazardous Substances Data: 167938-56-9(Hazardous Substances Data)

Usage

Chemical Properties

Clear and colorless liquid

Uses

(S)-1-(Boc-amino)-2-propanol is used as pharmaceutical intermediate.

InChI:InChI=1/C8H17NO3/c1-6(10)5-9-7(11)12-8(2,3)4/h6,10H,5H2,1-4H3,(H,9,11)/t6-/m0/s1

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 75-56-9 methyloxirane 
• 123-20-6 vinyl n-butyrate 
• 95656-86-3 tert-butyl 2-hydroxypropylcarbamate 

Downstream Products

• 129319-91-1 (R)-(-)-N-(tert-Butoxycarbonyl)-2-methylaziridine 
• 352303-74-3 3-[2-N-Boc-amino-1-(R)-methylethyl]-5-bromo-1-(2,6-difluorobenzyl)-6-methyluracil 
• 937375-79-6 (+)-tert-butyl (2S,3R)-3-methylaziridine-2-carboxylate 
• 181369-36-8 tert-butyl (S)-3-methyl-2H-azirine-2-carboxylate 
• 396074-50-3 (S)-5-methyl-2,2-dioxo[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester 
• 1338090-92-8 [(S)-2-(3-trifluoromethylphenyl)propyl]carbamic acid tert-butyl ester 
• 1399008-14-0 di-tert-butyl ((2S,2'S)-((2-iodo-1,3-phenylene)bis(oxy))bis(propane-2,1-diyl))dicarbamate 
• 1452925-35-7 C₁₅H₂₂INO₄ 
• 16066-84-5 N-(tert-butoxycarbonyl)methylamine 
• 1443216-71-4 C₂₇H₃₅N₅O₆ 
• 907546-01-4 tert-butyl N-[(2S)-2-methoxypropyl]carbamate 
• 675606-03-8 3-[2-N-Boc-amino-1-(R)-methylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil 

Relevant articles and documents

Asymmetric catalytic synthesis of enantiopure N-protected 1,2-amino alcohols

(Chemical Equation Presented) The asymmetric aminolytic kinetic resolution (AKR) of racemic terminal epoxides using carbamates as the nucleophile catalyzed by (salen)CoIII complex provides a practical and straightforward method for the synthesis of both aliphatic and aromatic N-Boc- or N-Cbz-protected 1,2-amino alcohols in almost enantiomerically pure form (ee ≥ 99%). The AKR uses an easily accessible catalyst and inexpensive starting materials, and the reactions are conveniently carried out at room temperature under an air atmosphere.