1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Name:1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide
CAS No.:1566543-09-6
Molecular Formula:C₂₀H₁₉ClF₂N₆O
Molecular Weight:432.86
Hs Code.:

Synonyms:1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Chemical Property of 1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

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Technology Process of 1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

There total 3 articles about 1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 1174309-16-0
1-(difluoromethyl)-1H-pyrazol-4-amine

: 1566543-84-7
1-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

: 1566543-09-6
1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 120 ℃; for 2h;

Reference yield:

: 1566543-59-6
1-(2-ethynyl phenyl)cyclopropanecarboxamide

: 1566543-09-6
1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triethylamine / 1,4-dioxane / 2.5 h / 60 °C / Inert atmosphere

2: hydrogen; platinum(IV) oxide; N-ethyl-N,N-diisopropylamine / methanol / 58 h

3: toluene-4-sulfonic acid / 1,4-dioxane / 2 h / 120 °C

With platinum(IV) oxide; copper(l) iodide; hydrogen; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol;

Reference yield:

: 1566543-83-6
1-(2-((2,5-dichloropyrimidin-4-yl)ethynyl)phenyl)cyclopropanecarboxamide

: 1566543-09-6
1-(2-(2-(5-chloro-2-((1-(difluoromethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; platinum(IV) oxide; N-ethyl-N,N-diisopropylamine / methanol / 58 h

2: toluene-4-sulfonic acid / 1,4-dioxane / 2 h / 120 °C

With platinum(IV) oxide; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol;