(Z)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole

Base Information

• Chemical Name: (Z)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole
• CAS No.: 1629870-93-4
• Molecular Formula: C₂₁H₂₂FNO₂S
• Molecular Weight: 371.476
• Mol file: 1629870-93-4.mol

Synonyms:(Z)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole

Chemical Property of (Z)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole

Chemical Property:

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Technology Process of (Z)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole

There total 1 articles about (Z)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide (1629870-87-6) → (Z)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole (1629870-93-4) + (E)-5-fluoro-3,3-dimethyl-1-2-(2-phenylethylidene)-[(4-tolyl)sulfonyl]-2,3-dihydro-1H-pyrrole (1629870-92-3)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 - 90 ℃; for 4h; Solvent; Temperature; Reagent/catalyst; Overall yield = 78 %; Overall yield = 35 mg; stereoselective reaction; Inert atmosphere;

DOI:10.1055/s-0033-1340857

upstream raw materials:

N-[4,4-difluoro-2,2-dimethyl-1-(2-phenylethyl)but-3-en-1-ylidene]-4-methylbenzenesulfonamide