1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene

Base Information

• Chemical Name: 1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene
• CAS No.: 868367-49-1
• Molecular Formula: C₅₆H₃₈O₂
• Molecular Weight: 742.917
• Mol file: 868367-49-1.mol

Synonyms:1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene

Chemical Property of 1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene

There total 3 articles about 1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-formylphenylboronic acid, (87199-17-5) + 4,4''-dibromo-3',4',5',6'-tetraphenyl-1,1':2',1''-terphenyl (22932-53-2) → 1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene (868367-49-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 90 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c5ra02909k

Reference yield:

4,4''-dibromo-3',4',5',6'-tetraphenyl-1,1':2',1''-terphenyl (22932-53-2) → 1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene (868367-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / diethyl ether; pentane / -78 - 20 °C

1.2: trimethyl borate / diethyl ether; pentane / -78 - 20 °C

1.3: aq. HCl / diethyl ether; pentane / 20 °C

2.1: 6.43 g / (PPh₃)4Pd; aq. Na₂CO₃ / toluene / 48 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium carbonate; In diethyl ether; toluene; pentane; 2.1: Suzuki coupling;

DOI:10.1021/ja0541985

Reference yield:

4-bromo-benzaldehyde (1122-91-4) + 1,2-bis[4-(dihydroxyboryl)phenyl]-3,4,5,6-tetraphenylbenzene (500568-06-9) → 1,2-bis[4-(4-formylphenyl)phenyl]-3,4,5,6-tetraphenylbenzene (868367-49-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; for 48h; Heating;

DOI:10.1021/ja0541985

upstream raw materials:

4-bromo-benzaldehyde

1,2-bis[4-(dihydroxyboryl)phenyl]-3,4,5,6-tetraphenylbenzene

4,4''-dibromo-3',4',5',6'-tetraphenyl-1,1':2',1''-terphenyl

4-formylphenylboronic acid,