5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Base Information

Chemical Name:5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one
CAS No.:344465-95-8
Molecular Formula:C₁₆H₁₃F₃N₄O₃S
Molecular Weight:398.365
Hs Code.:

5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2<i>H</i>-pyridazin-3-one

Synonyms:5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one

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Chemical Property of 5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one

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Technology Process of 5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one

There total 4 articles about 5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 344465-94-7
5-(2-Methylsulfanylpyrimidin-4-yl)-6-(3-trifluoromethylphenyl)-4,5-dihydro-2H-pyridazin-3-one

: 344465-95-8
5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: With sodium tungstate; dihydrogen peroxide; In methanol; ethyl acetate; for 24h; Heating;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

: 200801-88-3
2-(2-Methylsulfanylpyrimidin-4-yl)-1-(3-trifluoromethylphenyl)ethanone

: 344465-95-8
5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / dimethylsulfoxide

1.2: 86 percent / dimethylsulfoxide / 2 h / 20 °C

2.1: 78 percent / 6N HCl / dioxane / 24 h / 20 °C

3.1: 41 percent / N₂H₄ / ethanol / 4 h / Heating

4.1: 92 percent / 30 percent H₂O₂; Na₂WO₄*2H₂O / methanol; ethyl acetate / 24 h / Heating

With hydrogenchloride; sodium tungstate; dihydrogen peroxide; sodium hydride; hydrazine; In 1,4-dioxane; methanol; ethanol; dimethyl sulfoxide; ethyl acetate;
DOI:10.1016/S0960-894X(01)00834-4

Reference yield:

: 344465-92-5
3-(2-methylsulfanyl-pyrimidin-4-yl)-4-oxo-4-(3-trifluoromethyl-phenyl)-butyric acid methyl ester

: 344465-95-8
5-(2-methanesulfonyl-pyrimidin-4-yl)-6-(3-trifluoromethyl-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / 6N HCl / dioxane / 24 h / 20 °C

2: 41 percent / N₂H₄ / ethanol / 4 h / Heating

3: 92 percent / 30 percent H₂O₂; Na₂WO₄*2H₂O / methanol; ethyl acetate / 24 h / Heating

With hydrogenchloride; sodium tungstate; dihydrogen peroxide; hydrazine; In 1,4-dioxane; methanol; ethanol; ethyl acetate;
DOI:10.1016/S0960-894X(01)00834-4