200801-88-3

Upstream product

• 14001-63-9 2-methylthio-4-methylpyrimidine 
• 116332-62-8 N-methoxy-N-methyl-3-trifluoromethylbenzamide 
• 109-72-8 n-butyllithium 
• 2251-65-2 3-(Trifluoromethyl)benzoyl chloride 

Downstream Products

• 344465-92-5 3-(2-methylsulfanyl-pyrimidin-4-yl)-4-oxo-4-(3-trifluoromethyl-phenyl)-butyric acid methyl ester 
• 786705-11-1 4-[2-methyl-3-(2-methylsulfanyl-pyrimidin-4-yl)-4-oxo-4-(3-trifluoromethyl-phenyl)-butyryl]-piperidine-l-carboxylic acid benzyl ester 
• 200801-93-0 4-[5-(2-(4-methoxybenzylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-27-0 (S)-4-[5-[2-(1-phenylethylamino)-pyrimidin-4-yl]-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-25-8 (R)-4-[5-(2-(1-phenylethylamino)-pyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-99-6 (S)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole 
• 234767-12-5 (R)-5-<2-(1-phenylethylamino)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-benzyloxycarbonyl)piperidinyl>imidazole 
• 200801-92-9 5-<2-(methylsulfonyl)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole 
• 234767-11-4 4-[4-(2-methanesulfonyl-pyrimidin-4-yl)-1-methyl-5-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 
• 200801-95-2 5-<2-(methylsulfonyl)pyrimidin-4-yl>-1-methyl-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole 
• 200801-20-3 4-methoxybenzyl-[4-[2-piperidin-4-yl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]-pyrimidin-2-yl]amine 
• 200801-90-7 4-[1-hydroxy-5-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid benzyl ester 
• 200801-91-8 5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole 
• 219646-44-3 4-[4-(2-methylthiopyrimidin-4-yl)-1-methyl-5-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

MODULATORS OF HCV REPLICATION

The present invention is directed to the use of certain 2,4,5-trisubstituted imidazole derivatives in modulating the replication of Hepatitis C virus RNA and/or virus production in cells.

Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase

Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition o

SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY

Compounds represented by formula I: I are disclosed. AR represents an aromatic group containing 6-10 atoms; and represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional

PYRAZOLOPYRIDINE DERIVATES

New compounds of formula (I) and the salts, solvates and prodrugs thereof, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.

SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE

The present invention relates to compounds having the general formula [I] or a pharmaceutically acceptable salt thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititi

Compounds having cytokine inhibitory activity

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.

Substituted imidazoles having cytokine inhibitory activity

Compounds represented by formula I: STR1 are disclosed. AR represents an aromatic group containing 6-10 atoms; and STR2 represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additio

Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase

Novel potent and selective diarylimidazole inhibitors of p38 MAP (mitogen-activated protein) kinase are described which have activity in both cell-based assays of tumor necrosis factor-α (TNF-α) release and an animal model of rheumatoid arthritis. The SAR