5-BROMO-6-NITRO-1H-INDAZOLE

Base Information

• Chemical Name: 5-BROMO-6-NITRO-1H-INDAZOLE
• CAS No.: 71785-49-4
• Molecular Formula: C7H4 Br N3 O2
• Molecular Weight: 242.032
• Hs Code.: 2933990090
• Mol file: 71785-49-4.mol

Synonyms:5-Bromo-6-nitro-1H-indazole

Chemical Property of 5-BROMO-6-NITRO-1H-INDAZOLE

Chemical Property:

• Boiling Point: 389.6±22.0 °C(Predicted)
• PKA: 9.82±0.40(Predicted)
• PSA: 74.50000
• Density: 1.965±0.06 g/cm3(Predicted)
• LogP: 2.75680
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-6-nitro-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-6-NITRO-1H-INDAZOLE

There total 3 articles about 5-BROMO-6-NITRO-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-bromo-2-methyl-5-nitroaniline (71785-48-3) → 5-bromo-6-nitro-1H-indazole (71785-49-4)

Guidance literature:

With acetic acid; sodium nitrite; In water; at 20 ℃; for 72h;

DOI:10.1016/j.bmc.2007.01.010

Reference yield:

4-bromo-2-methylaniline hydrochloride (13194-70-2) → 5-bromo-6-nitro-1H-indazole (71785-49-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / H₂SO₄; KNO₃ / 20 °C

2: 63 percent / acetic acid; sodium nitrite / H₂O / 72 h / 20 °C

With sulfuric acid; acetic acid; potassium nitrate; sodium nitrite; In water;

DOI:10.1016/j.bmc.2007.01.010

Reference yield:

→ 5-bromo-6-nitro-1H-indazole (71785-49-4)

Guidance literature:

4-Brom-2-methyl-5-nitroanilin (3), NaNO2;

DOI:10.1021/jo00393a032

upstream raw materials:

4-bromo-2-methyl-5-nitroaniline

4-bromo-2-methylaniline hydrochloride

Downstream raw materials:

5-bromo-6-nitro-1H-indazole-1-carboxylic acid tert-butyl ester

5-bromo-3-chloro-6-nitro-1H-indazole

tert-butyl 5-bromo-6-amino-1H-indazole-1-carboxylate

tert-butyl 5-bromo-3-chloro-6-nitro-1H-indazole-1-carboxylate

Refernces