(E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

Base Information

Chemical Name:(E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane
CAS No.:1259026-15-7
Molecular Formula:C₁₈H₂₁BO₂
Molecular Weight:280.175
Hs Code.:

Synonyms:(E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

Suppliers and Price of (E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

Chemical Property:

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Technology Process of (E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

There total 1 articles about (E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,2,6,6-tetramethyl-1-(1-(naphthalene-2-yl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethoxy)piperidine

: 827-54-3,28406-56-6
2-naphthylethylene

: 1259026-15-7
(E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

Guidance literature:: In 1,2-dichloro-ethane; at 80 ℃; for 18h; Schlenk technique; Inert atmosphere; Sealed tube; Glovebox;
DOI:10.1021/acs.orglett.8b03599

Reference yield:

: 1259026-15-7
(E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

: 1374000-02-8
(1R,4R,5R)-1,4,5-trihydroxy-3-(2-(naphth-2-yl)ethyl)cyclohex-2-ene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 80 °C / Inert atmosphere

2.1: hydrogen / tetrahydrofuran; methanol; water / 2.5 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 0.17 h / 20 °C

4.2: Amberlite IR-120 / 20 °C / pH 6

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; hydrogen; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1.1: Suzuki coupling;
DOI:10.1039/c2ob07081b

Reference yield:

: 1259026-15-7
(E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane

: 1374000-04-0
(1R,4R,5R)-1,4,5-trihydroxy-3-(2-(5,6,7,8-tetrahydronaphth-2-yl)ethyl)cyclohex-2-ene-1-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 3.5 h / 80 °C / Inert atmosphere

2.1: Pd-BaSO₄; hydrogen / tetrahydrofuran; methanol / 12 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; water / 0.17 h / 20 °C

4.2: Amberlite IR-120 / 20 °C / pH 6

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd-BaSO₄; tetrabutyl ammonium fluoride; hydrogen; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1.1: Suzuki coupling;
DOI:10.1039/c2ob07081b