1374000-02-8

Basic information

• Product Name: (1R,4R,5R)-1,4,5-trihydroxy-3-(2-(naphth-2-yl)ethyl)cyclohex-2-ene-1-carboxylic acid
• Synonyms: (1R,4R,5R)-1,4,5-trihydroxy-3-(2-(naphth-2-yl)ethyl)cyclohex-2-ene-1-carboxylic acid
• CAS NO: 1374000-02-8
• Molecular Weight: 328.365
• Mol File: 1374000-02-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,4R,5R)-1,4,5-trihydroxy-3-(2-(naphth-2-yl)ethyl)cyclohex-2-ene-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4R,5R)-1,4,5-trihydroxy-3-(2-(naphth-2-yl)ethyl)cyclohex-2-ene-1-carboxylic acid(1374000-02-8)
• EPA Substance Registry System: (1R,4R,5R)-1,4,5-trihydroxy-3-(2-(naphth-2-yl)ethyl)cyclohex-2-ene-1-carboxylic acid(1374000-02-8)

Safety Data

• Hazardous Substances Data: 1374000-02-8(Hazardous Substances Data)

Upstream product

• 40231-00-3 trimethyl(2-(naphthalen-2-yl)ethynyl)silane 
• 2949-26-0 2-ethynylnaphthalene 
• 827-54-3 2-naphthylethylene 
• 580-13-2 2-bromonaphthalene 
• 1259026-02-2 (1R,4R,5R)-1,4-dihydroxy-3-(2-(naphth-2-yl)ethyl)cyclohex-2-en-1,5-carbolactone 
• 1259025-97-2 (1R,4R,5R)-1,4-di(tert-butyldimethylsilyloxy)-3-(2-(naphthalen-2-yl)ethyl)cyclohex-2-en-1,5-carbolactone 
• 1259026-31-7 (1R,4R,5R)-1,4-di(tert-butyldimethylsilyloxy)-3-((E)-2-(naphth-2-yl)vinyl)cyclohex-2-en-1,5-carbolactone 
• 1259026-15-7 (E)-1-(4’,4’,5’,5’-tetramethyl)-1’,3’,2’-dioxaboronalyl-2-(2’’-naphtalen-1’’-yl)ethane 
• 862791-05-7 (1R,4S,5R)-1,4-di(tert-butyldimethylsilyloxy)cyclohex-2-en-1,5-carbolactone 3-(trifluoromethane sulphonate) 

Relevant articles and documents

Synthesis of 3-alkyl enol mimics inhibitors of type II dehydroquinase: Factors influencing their inhibition potency

Several 3-alkylaryl mimics of the enol intermediate in the reaction catalyzed by type II dehydroquinase were synthesized to investigate the effect on the inhibition potency of replacing the oxygen atom in the side chain by a carbon atom. The length and the rigidity of the spacer was also studied. The inhibitory properties of the reported compounds against type II dehydroquinase from Mycobacterium tuberculosis and Helicobacter pylori are also reported. The binding modes of these analogs in the active site of both enzymes were studied by molecular docking using GOLD 5.0 and dynamic simulations studies.