[(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester

Base Information

• Chemical Name: [(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester
• CAS No.: 1208094-50-1
• Molecular Formula: C₂₁H₂₆N₂O₄
• Molecular Weight: 370.448
• Mol file: 1208094-50-1.mol

Synonyms:[(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester

Chemical Property of [(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of [(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester

There total 1 articles about [(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-aminobenzenemethanol (623-04-1) + (S)-1-(N-tert-butoxycarbonyl-N-methylamino)-1-phenylacetic acid (30925-08-7,30925-12-3,30925-11-2) → [(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester (1208094-50-1)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 2h;

DOI:10.1016/j.bmcl.2009.11.020

Reference yield: 98.0%

[(4-hydroxymethylphenylcarbamoyl)phenylmethyl]methylcarbamic acid tert-butyl ester (1208094-50-1) → C16H18N2O2 (1228174-26-2)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 0.25h;

DOI:10.1016/j.bmcl.2009.11.020

upstream raw materials:

4-aminobenzenemethanol

(S)-1-(N-tert-butoxycarbonyl-N-methylamino)-1-phenylacetic acid

Downstream raw materials:

C₁₆H₁₈N₂O₂