N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

Base Information

Chemical Name:N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide
CAS No.:1638769-12-6
Molecular Formula:C₃₁H₃₆N₆O₅
Molecular Weight:572.664
Hs Code.:

Synonyms:N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

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Chemical Property of N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

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Technology Process of N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

There total 6 articles about N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1638769-11-5
[(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine)-2-carboxamide]-2-[(3-methylpentanoyl)-amino]-3-phenylpropionic acid hydrazide

: 141-97-9
ethyl acetoacetate

: 1638769-12-6
N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

Guidance literature:: With piperidine; In ethanol; for 8h; Reflux;
DOI:10.5560/ZNB.2014-4031

Reference yield:

: 18598-74-8
methyl L-isoleucinate hydrochloride

: 1638769-12-6
N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; chloroformic acid ethyl ester

2.1: sodium hydroxide

3.1: triethylamine; chloroformic acid ethyl ester / dichloromethane / 0.17 h / -20 °C

3.2: 3 h / -20 - 20 °C

4.1: hydrazine hydrate / methanol / 6 h / Reflux

5.1: piperidine / ethanol / 8 h / Reflux

With piperidine; chloroformic acid ethyl ester; hydrazine hydrate; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane;
DOI:10.5560/ZNB.2014-4031

Reference yield:

: 389-08-2
nalidixic Acid

: 1638769-12-6
N-(1-(1-(3-methyl-5-oxopyrazol-2-yl)-2-phenylethylcarbamoyl)-2-methylbutyl)-1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; chloroformic acid ethyl ester

2.1: sodium hydroxide

3.1: triethylamine; chloroformic acid ethyl ester / dichloromethane / 0.17 h / -20 °C

3.2: 3 h / -20 - 20 °C

4.1: hydrazine hydrate / methanol / 6 h / Reflux

5.1: piperidine / ethanol / 8 h / Reflux

With piperidine; chloroformic acid ethyl ester; hydrazine hydrate; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane;
DOI:10.5560/ZNB.2014-4031