4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone

Base Information

• Chemical Name: 4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone
• CAS No.: 1448451-02-2
• Molecular Formula: C₁₃H₁₅BrO₂
• Molecular Weight: 283.165
• Mol file: 1448451-02-2.mol

Synonyms:4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone

Chemical Property of 4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone

There total 1 articles about 4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

methyl propargyl alcohol (764-01-2) + 4-(3-bromopropyl)phenol (52273-55-9) → 4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone (1448451-02-2)

Guidance literature:

With [bis(acetoxy)iodo]benzene; at 0 - 20 ℃;

DOI:10.1021/ja404593c

Reference yield: 70.0%

4-(3-bromopropyl)-4-(but-2-yn-1-yloxy)cyclohexa-2,5-dienone (1448451-02-2) + 1,4-dibenzyloxybut-2-yne (93877-21-5) → 4,5-bis((benzyloxy)methyl)-8a-(3-bromopropyl)-3-methyl-2,2a1,5a,8a-tetrahydro-6H-naphtho[1,8-bc]furan-6-one

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; In toluene; at 80 ℃; for 5h; Molecular sieve; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2020.131862

upstream raw materials:

methyl propargyl alcohol

4-(3-bromopropyl)phenol