[Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester

Base Information

• Chemical Name: [Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester
• CAS No.: 137105-49-8
• Molecular Formula: C₁₃H₂₁O₅P
• Molecular Weight: 288.28
• Mol file: 137105-49-8.mol

Synonyms:[Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester

Chemical Property of [Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester

There total 1 articles about [Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

o-anisaldehyde dimethyl acetal (58378-33-9) + triethyl phosphite (122-52-1) → [Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester (137105-49-8)

Guidance literature:

With boron trifluoride diethyl etherate; at -20 ℃;

DOI:10.1039/c39910000972

Reference yield:

2-(2,2-Diethoxy-ethylsulfanyl)-benzaldehyde (137105-47-6) + [Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester (137105-49-8) → C22H28O4S (137105-50-1) + C22H28O4S (137105-64-7)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 2.) DME, reflux, 24 h;

DOI:10.1039/c39910000972

Reference yield:

[Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester (137105-49-8) → (6,7-Dimethoxy-2H-thiochromen-4-yl)-(2-hydroxy-phenyl)-methanone (137105-57-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) lithium diisopropylamide / 2.) DME, reflux, 24 h

2: 1.) TiCl₄, 2.) HCl / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, methanol, reflux

3: boron tribromide / -78 °C

With hydrogenchloride; boron tribromide; titanium tetrachloride; lithium diisopropyl amide;

DOI:10.1039/c39910000972

upstream raw materials:

o-anisaldehyde dimethyl acetal

triethyl phosphite

Downstream raw materials:

C₂₂H₂₈O₄S

C₂₂H₂₈O₄S

1-(2,2-Diethoxy-ethylsulfanyl)-4,5-dimethoxy-2-[(Z)-2-methoxy-2-(2-methoxy-phenyl)-vinyl]-benzene

(6,7-Dimethoxy-2H-thiochromen-4-yl)-(2-hydroxy-phenyl)-methanone