1-(Dimethoxymethyl)-2-methoxybenzene

Base Information

• Chemical Name: 1-(Dimethoxymethyl)-2-methoxybenzene
• CAS No.: 58378-33-9
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• European Community (EC) Number: 881-659-9
• UNII: 7YA7TC36KK
• DSSTox Substance ID: DTXSID00992178
• Nikkaji Number: J406.166G
• Wikidata: Q82982222
• Mol file: 58378-33-9.mol

Synonyms:1-(dimethoxymethyl)-2-methoxybenzene;58378-33-9;SCHEMBL1918798;DTXSID00992178;methoxybenzaldehyde dimethyl acetal;AKOS038065207;F72170;EN300-7472873

Chemical Property of 1-(Dimethoxymethyl)-2-methoxybenzene

Chemical Property:

• PSA: 27.69000
• LogP: 1.98660
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 134

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(OC)OC
• Uses: 1-?(Dimethoxymethyl)?-?2-?methoxybenzene is a useful reagent in the preparation of acyclic and semicyclic O?/O acetals.

Technology Process of 1-(Dimethoxymethyl)-2-methoxybenzene

There total 5 articles about 1-(Dimethoxymethyl)-2-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ortho-anisaldehyde (135-02-4) + trimethyl orthoformate (149-73-5) → o-anisaldehyde dimethyl acetal (58378-33-9)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; at 32 ℃;

Reference yield: 94.0%

trifluoroacetic acid-methyl ester (431-47-0) + sodium methylate (124-41-4) + ortho-anisaldehyde (135-02-4) → o-anisaldehyde dimethyl acetal (58378-33-9)

Guidance literature:

In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1039/c8ob00017d

Reference yield: 91.0%

methanol (67-56-1) + ortho-anisaldehyde (135-02-4) → o-anisaldehyde dimethyl acetal (58378-33-9)

Guidance literature:

With phosphoric acid functionalized ethanolamine grafted polyacrylonitrile fiber; at 65 ℃; for 0.5h; Green chemistry;

DOI:10.1002/asia.201700846

upstream raw materials:

ortho-anisaldehyde

trimethyl orthoformate

methanol

salicylaldehyde

Downstream raw materials:

[Methoxy-(2-methoxy-phenyl)-methyl]-phosphonic acid diethyl ester

α-methoxy-2-methoxybenzyl-triethylphosphonium bromide

ortho-anisaldehyde

ethyl 2-oxo-4-(o-methoxyphenyl)but-3-enoate