2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide

Base Information

Chemical Name:2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide
CAS No.:221060-80-6
Molecular Formula:C₁₃H₁₂BrNO₂S
Molecular Weight:326.214
Hs Code.:

Synonyms:2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide

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Chemical Property of 2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide

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Technology Process of 2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide

There total 5 articles about 2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29421-92-9
4-bromo-2-methylthiophene

: 221060-80-6
2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / dimethyl ether; hexane / 1 h / -70 °C

1.2: 54 percent / dimethyl ether / 0.5 h / -70 °C

2.1: 72 percent / bromine / acetic acid / 3 h / 20 °C

3.1: thionyl chloride / 1.25 h / Heating

4.1: pyridine / toluene / 6 h / 20 °C

With pyridine; n-butyllithium; thionyl chloride; bromine; In hexane; Dimethyl ether; acetic acid; toluene;
DOI:10.1002/jhet.5570390124

Reference yield:

: 2835-97-4
2-amino-3-methylphenol

: 221060-79-3
2-Bromo-5-methyl-3-thiophenecarbonyl chloride

: 221060-80-6
2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide

Guidance literature:: With pyridine; In toluene; at 20 ℃; for 6h;
DOI:10.1002/jhet.5570390124

Reference yield:

: 19156-50-4
5-methyl-thiophene-3-carboxylic acid

: 221060-80-6
2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / bromine / acetic acid / 3 h / 20 °C

2: thionyl chloride / 1.25 h / Heating

3: pyridine / toluene / 6 h / 20 °C

With pyridine; thionyl chloride; bromine; In acetic acid; toluene;
DOI:10.1002/jhet.5570390124