19156-50-4

Usage

Uses

Used in Pharmaceutical Synthesis:
5-methylthiophene-3-carboxylic acid is utilized as a key intermediate in the development of pharmaceuticals due to its ability to form diverse functionalized thiophene derivatives. Its unique structure allows for the creation of novel drug candidates with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 5-methylthiophene-3-carboxylic acid serves as a valuable precursor for the synthesis of various agrochemicals. Its incorporation into these compounds can enhance their effectiveness in crop protection and pest management.
Used in Organic Synthesis:
5-methylthiophene-3-carboxylic acid is employed as a versatile starting material in organic synthesis. Its reactivity and structural features make it suitable for the preparation of a wide range of thiophene-based compounds, which can be applied in various chemical and material science fields.
Used in Chemical Research:
As a building block for the synthesis of complex organic molecules, 5-methylthiophene-3-carboxylic acid is also used in chemical research to explore new reaction pathways and develop innovative synthetic methods. This contributes to the advancement of organic chemistry and the discovery of new compounds with unique properties and applications.

InChI:InChI=1/C6H6O2S/c1-4-2-5(3-9-4)6(7)8/h2-3H,1H3,(H,7,8)

Upstream product

• 16494-35-2 4-iodo-2-methyl-thiophene 
• 29421-92-9 4-bromo-2-methylthiophene 
• 124-38-9 carbon dioxide 
• 554-14-3 2-Methylthiophene 
• 16494-47-6 3,4,5-triiodo-2-methylthiophene 
• 88770-18-7 methyl 5-methyl-3-thiophenecarboxylate 

Downstream Products

• 221060-70-4 2-bromo-N-(2-hydroxyphenyl)-5-methyl-3-thiophenecarboxamide 
• 221060-77-1 2-bromo-N-(4-chloro-2-hydroxyphenyl)-5-methyl-3-thiophenecarboxamid 
• 221060-76-0 2-bromo-N-(5-chloro-2-hydroxyphenyl)-5-methyl-3-thiophenecarboxamid 
• 221060-80-6 2-bromo-N-(2-hydroxy-6-methylphenyl)-5-methyl-3-thiophenecarboxamide 
• 440359-53-5 2-bromo-N-(2-hydroxy-3-methylphenyl)-5-methyl-3-thiophenecarboxamide 
• 221060-74-8 2-bromo-N-(2-hydroxy-4-methylphenyl)-5-methyl-thiophene-3-carboxamide 
• 221060-75-9 2-bromo-N-(2-hydroxy-5-methylphenyl)-5-methyl-3-thiophenecarboxamide 
• 221060-78-2 2-bromo-N-(2-hydroxy-4-methoxyphenyl)-5-methyl-3-thiophenecarboxamide 
• 221060-81-7 2-bromo-N-(2-hydroxy-3-methoxyphenyl)-5-methyl-3-thiophenecarboxamide 
• 1351753-32-6 C₁₃H₉BrO₂S 
• 754190-97-1 C₆H₅ClOS 
• 1351753-36-0 C₁₅H₁₄BrN₃OS 
• 1334326-58-7 C₁₉H₁₇N₅OS 
• 1262880-53-4 ethyl 6-[2-(2-tert-butoxycarbonylamino-4-methoxyphenyl)-3-oxo-3-thiophen-3-ylpropyl]pyridine-2-carboxylate 

Relevant academic research and scientific papers

(THIENO[2,3-b][1,5]BENZOXAZEPIN-4-YL)PIPERAZIN-1-YL COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS

A dual H1 inverse agonist/5-HT2A receptor antagonist of the formula (I), its uses, and methods for its preparation are described.

Synthesis of thieno[2,3-b][1,5]benzoxazepine derivatives

A new series of 4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepines 1a-k has been synthesized from 4-bromo-2-methylthiophene 6 or ethyl 2-amino-4,5-dimethyl-3-thiophencarboxylate 10. Preparation of the key intermediate thieno[2,3-b][1,5]benzoxazepine-4(5H)-ones 4a-i, 4k were carried out by treatment of 2-bromo-N-(2-hydroxyphenyl)-3-thiophencarboxamides 5a-i, 5k with potassium carbonate in DMSO. Compounds 1 are thienoanalogues of loxapine, a potent antipsychotic drug. Of these compounds, the neuroleptic activity of 2-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepine 1a (R1, R3=H, R2=CH3) demonstrated potent antipsychotic activity.