(S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole

Base Information

• Chemical Name: (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole
• CAS No.: 105329-93-9
• Molecular Formula: C₁₇H₁₉Br₂N₃O₃
• Molecular Weight: 473.164
• Mol file: 105329-93-9.mol

Synonyms:(S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole

Chemical Property of (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole

There total 4 articles about (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

aqueous NaHSO3 + (S)-2-<phenyl>methyl>imidazole (102152-01-2) → (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole (105329-93-9)

Guidance literature:

With bromine; sodium acetate; In 1,4-dioxane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate; glacial HOAc; acetic acid;

Reference yield:

2-<(-methoxyphenyl)methyl>imidazole (102151-99-5) → (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole (105329-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / HBr / acetic acid / 2.5 h / Heating

2: 1.) NaH / 1.) Me₂SO, 60 deg C, 15 min, 2.) Me₂SO, a) 60 deg C, 3 h, b) RT, overnight

3: 1.) NaOAc, 2.) Br₂ / 1.) HOAc, 15 deg C, 2.) HOAc

With hydrogen bromide; bromine; sodium acetate; sodium hydride; In acetic acid;

DOI:10.1021/jm00156a028

Reference yield:

(S)-2-<phenyl>methyl>imidazole (102152-01-2) → (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole (105329-93-9)

Guidance literature:

With bromine; sodium acetate; Multistep reaction; 1.) HOAc, 15 deg C, 2.) HOAc;

DOI:10.1021/jm00156a028

upstream raw materials:

(S)-2-<phenyl>methyl>imidazole

2-<(-methoxyphenyl)methyl>imidazole

2-(p-Hydroxyphenylmethyl)imidazole

Downstream raw materials:

(S)-4-bromo-2-<<4-(3-isopropyl-2-hydroxypropoxy)phenyl>methyl>imidazole

(S)-4-bromo-2-<phenyl>methyl>imidazole