102151-99-5

Usage

Structure

A derivative of imidazole (a five-membered heterocyclic ring) with a methoxyphenylmethyl group attached at the 2-position.

Usage

Commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals.

Biological and pharmacological activities

Possesses antifungal, antimicrobial, and anti-inflammatory properties, making it valuable in drug discovery and development.

Organic synthesis

Used as a versatile intermediate for the preparation of various functionalized imidazole derivatives with potential applications in medicinal chemistry and material science.

Upstream product

• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 131543-46-9 Glyoxal 
• 71609-39-7 4-Methoxytolazoline 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 33675-41-1 1-bromo-2-(4-methoxyphenyl)acetylene 

Downstream Products

• 105329-92-8 2-(p-Hydroxyphenylmethyl)imidazole 
• 102151-22-4 (S)-4-bromo-2-<<4-(3-isopropyl-2-hydroxypropoxy)phenyl>methyl>imidazole 
• 102152-01-2 (S)-2-<phenyl>methyl>imidazole 
• 102152-02-3 (S)-4-bromo-2-<phenyl>methyl>imidazole 
• 105329-93-9 (S)-4,5-Dibromo-2-{[p-(3-isopropyloxazolid-2-on-5-yl)methoxy]phenylmethyl}imidazole 
• 114798-79-7 N-{4-[2-(4-Methoxy-benzyl)-imidazol-1-ylmethyl]-phenyl}-phthalamic acid 

Relevant academic research and scientific papers

Novel, mild and chemoselective dehydrogenation of 2-imidazolines with trichloroisocyanuric acid

A rapid, mild and high-yielding method for dehydrogenation of a variety of structurally diverse 2-imidazolines to imidazoles jusing trichloroisocyanuric acid (TCCA) in the presence of DBU is reported. Chemoselective oxidation of 2-imidazolines can be achieved in the presence of sulfide and alcohol. The mild conditions of this procedure and the absence of any transition metal make this reaction suitable for safe laboratory use.

A novel synthetic method for 2-arylmethyl substituted imidazolines and imidazoles from 2-aryl-1,1-dibromoethenes

Various 2-arylmethylimidazolines were prepared by treating readily available 2-aryl-1,1-dibromoethenes with ethylenediamine under mild conditions and further converted into the corresponding imidazoles smoothly with Swern oxidation. Graphical Abstract

Novel substituted imidazoles, their preparation and use

Novel substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit cardioselective β-adrenergic blocking activity, and are useful as antihypertensive agents, cardioprotective agents, antiarrythmic agen

β1-Selective Adrenoceptor Antagonists: Examples of the 2-phenyl>imidazole Class. 2

An attempt to develop a highly cardioselective β-adrenoceptor antagonist devoid of intrinsic sympathomimetic activity (ISA) focused on exploring structure-activity relationships around (S)--amino>-2-hydroxypropoxy>phen