rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid

Base Information

Chemical Name:rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid
CAS No.:1360966-49-9
Molecular Formula:C₂₈H₂₂N₂O₄
Molecular Weight:450.494
Hs Code.:

Synonyms:rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid

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Chemical Property of rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid

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Technology Process of rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid

There total 16 articles about rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: bis{4-[2-(4-pyridyl)ethenyl]} benzoic acid

: 1360966-49-9
rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid

Guidance literature:: With oxalic acid; In cyclohexane; at 35 ℃; for 16h; stereoselective reaction; UV-irradiation;
DOI:10.1002/chem.201905597

Reference yield:

: 108-89-4
picoline

: 1360966-49-9
rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: acetic anhydride / 16 h / Reflux

2: thionyl chloride / 12 h / 20 °C

3: -10 - 20 °C

4: ethanol / Reflux

5: 10 h / UV-irradiation

6: water; sodium hydroxide / 2 h

7: hydrogenchloride / water

With hydrogenchloride; thionyl chloride; water; acetic anhydride; sodium hydroxide; In ethanol; water;
DOI:10.1002/anie.201106842

Reference yield:

: 53031-56-4
4-[(E)-2-(pyridine-4-yl)ethenyl]benzoic acid

: 1360966-49-9
rac-4,4'-((1R,2S,3R,4S)-3,4-di(pyridin-4-yl)cyclobutane-1,2-diyl)dibenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 12 h / 20 °C

2: -10 - 20 °C

3: ethanol / Reflux

4: 10 h / UV-irradiation

5: water; sodium hydroxide / 2 h

6: hydrogenchloride / water

With hydrogenchloride; thionyl chloride; water; sodium hydroxide; In ethanol; water;
DOI:10.1002/anie.201106842