4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile

Base Information

Chemical Name:4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile
CAS No.:1250440-80-2
Molecular Formula:C₁₆H₁₈BrNO₃
Molecular Weight:352.228
Hs Code.:

Synonyms:4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile

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Chemical Property of 4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile

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Technology Process of 4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile

There total 4 articles about 4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: C₁₇H₁₉NO₅

: 1250440-80-2
4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile

Guidance literature:: With Bromotrichloromethane; dicyclohexyl-carbodiimide; 2-mercaptopyridine N-oxide; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/jm5005122

Reference yield:

: 56209-56-4
2-((2S,4S)-2-(tert-butyl)-5-oxo-1,3-dioxolan-4-yl)acetic acid

: 1250440-80-2
4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 - -40 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; 2-mercaptopyridine N-oxide; Bromotrichloromethane / 2 h / Inert atmosphere; Reflux

With Bromotrichloromethane; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; 2-mercaptopyridine N-oxide; In tetrahydrofuran;
DOI:10.1021/jm5005122

Reference yield:

: 17201-43-3
4-cyanobenzyl bromide

: 1250440-80-2
4-[(2S,4R)-4-(bromomethyl)-2-tert-butyl-5-oxo-1,3-dioxolan-4-yl-methyl]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 - -40 °C / Inert atmosphere

2.1: dicyclohexyl-carbodiimide; 2-mercaptopyridine N-oxide; Bromotrichloromethane / 2 h / Inert atmosphere; Reflux

With Bromotrichloromethane; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; 2-mercaptopyridine N-oxide; In tetrahydrofuran;
DOI:10.1021/jm5005122