trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

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Chemical Name:trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine
CAS No.:1400872-85-6
Molecular Formula:C₂₀H₂₂N₁₀
Molecular Weight:402.462
Hs Code.:

Synonyms:trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

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Chemical Property of trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

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Technology Process of trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

There total 7 articles about trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 1330596-44-5
tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

: 1400872-85-6
trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Guidance literature:: 2-chloropyrimidine; tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate; With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In 1,4-dioxane; at 90 ℃; for 10h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; for 2h;

Reference yield: 10.0%

: C₂₅H₃₀N₁₀O₂

: 1400872-85-6
trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; for 2h;
DOI:10.1021/jm500342d

Reference yield:

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 1400872-85-6
trans-N-{3-[2-(pyrimidin-2-ylamino)pyrimidin-5-yl]imidazo[1,2-b]pyridazin-6-yl}cyclohexane-1,4-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 30 h / 180 °C / microwave irradiation

2.1: dmap; triethylamine / tetrahydrofuran / 18 h / Reflux

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 90 °C / Inert atmosphere

4.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 10 h / 90 °C / Inert atmosphere

4.2: 2 h

With dmap; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water;