tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

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Chemical Name:tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate
CAS No.:1330596-44-5
Molecular Formula:C₂₁H₂₈N₈O₂
Molecular Weight:424.506
Hs Code.:

Synonyms:tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

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Chemical Property of tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

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Technology Process of tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

There total 4 articles about tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1330595-43-1
tert-butyl {trans-4-[(3-bromoimidazo[1,2-b]pyridazin-6-yl)amino]cyclohexyl}carbamate

: 1330596-44-5
tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

Guidance literature:: With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 90 ℃; for 5h; Inert atmosphere;

Reference yield:

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 1330596-44-5
tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 30 h / 180 °C / microwave irradiation

2: dmap; triethylamine / tetrahydrofuran / 18 h / Reflux

3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 90 °C / Inert atmosphere

With dmap; caesium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 1330595-42-0
trans-N-(3-bromo-imidazo[1,2-b]pyridazin-6-yl)-cyclohexane-1,4-diamine

: 1330596-44-5
tert-butyl (trans-4-{[3-(2-bminopyrimidin-5-yl)imidazo[1,2-b]pyridazin-6-yl]amino}cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / tetrahydrofuran / 18 h / Reflux

2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 5 h / 90 °C / Inert atmosphere

With dmap; caesium carbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; water;