4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride

Base Information

• Chemical Name: 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride
• CAS No.: 57975-84-5
• Molecular Formula: C₁₇H₁₁F₃N₂O₂*ClH
• Molecular Weight: 368.743

Synonyms:4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride

Chemical Property of 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride

Chemical Property:

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Technology Process of 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride

There total 1 articles about 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-7-trifluoromethyl quinoline (346-55-4) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride (57975-84-5)

Guidance literature:

In ethanol; for 4h; Heating;

DOI:10.1021/jm00151a021

Reference yield: 86.0%

4-(3-trifluoromethylphenyl)-4-hydroxy piperidine (2249-28-7) + 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride (57975-84-5) + 1,1'-carbonyldiimidazole (530-62-1) → 4-[3-(trifluoromethyl)phenyl]-4-hydroxy-1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperidine (71916-46-6)

Guidance literature:

In N-methyl-acetamide;

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 4-<<7-(trifluoromethyl)-4-quinolinyl>amino>benzoic acid hydrochloride (57975-84-5) → C20H15F3N2O4

Guidance literature:

With triethylamine; In chloroform; at 0 ℃; for 3h;

DOI:10.1021/jm00151a021

upstream raw materials:

4-chloro-7-trifluoromethyl quinoline

4-amino-benzoic acid

Downstream raw materials:

Imidazol-1-yl-[4-(7-trifluoromethyl-quinolin-4-ylamino)-phenyl]-methanone

4-(3-methylphenyl)-4-hydroxy-1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]piperidine

4-phenyl-1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]-benzoyl]piperidine

4-(3-methylphenyl)-1,2,5,6-tetrahydro-1-[4-[[7-(trifluoromethyl)-4-quinolinyl]amino]benzoyl]pyridine

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