(4-Phenyl-1,3-thiazol-2-yl)methanol

Base Information

• Chemical Name: (4-Phenyl-1,3-thiazol-2-yl)methanol
• CAS No.: 65384-99-8
• Molecular Formula: C10H9 N O S
• Molecular Weight: 191.254
• Hs Code.: 2934100090
• European Community (EC) Number: 823-999-2
• DSSTox Substance ID: DTXSID20351384
• Wikidata: Q82127771
• Mol file: 65384-99-8.mol

Synonyms:(4-phenyl-1,3-thiazol-2-yl)methanol;65384-99-8;(4-phenylthiazol-2-yl)methanol;4-Phenylthiazole-2-methanol;MFCD00551809;2-Hydroxymethyl-4-phenylthiazole;Maybridge3_005031;Cambridge id 5156927;CBDivE_015895;SCHEMBL1745076;DTXSID20351384;TYUWZKSJURGPRJ-UHFFFAOYSA-N;HMS1445E15;2-(Hydroxymethyl)-4-phenylthiazole;AC6548;STL575507;AKOS005174958;IDI1_016418;LS-04811;SY174496;CS-0248754;FT-0683979;EN300-41277;A914270;SR-01000389605;SR-01000389605-1;Z415737292

Chemical Property of (4-Phenyl-1,3-thiazol-2-yl)methanol

Chemical Property:

• Boiling Point: 350.6±25.0 °C(Predicted)
• PKA: 13.06±0.10(Predicted)
• PSA: 61.36000
• Density: 1.264±0.06 g/cm3(Predicted)
• LogP: 2.30240
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 191.04048508
• Heavy Atom Count: 13
• Complexity: 159

Purity/Quality:

97% ^*data from raw suppliers

(4-Phenyl-1,3-thiazol-2-yl)methanolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CSC(=N2)CO

Technology Process of (4-Phenyl-1,3-thiazol-2-yl)methanol

There total 7 articles about (4-Phenyl-1,3-thiazol-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(4-phenylthiazol-2-yl)methyl benzoate (110704-59-1) → 2-hydroxymethyl-4-phenylthiazole (65384-99-8)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 1h; Cooling with ice;

Reference yield: 86.0%

ethyl 4-phenyl-1,3-thiazole-2-carboxylate (31877-30-2) → 2-hydroxymethyl-4-phenylthiazole (65384-99-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at -40 - 20 ℃; for 3.33h; Inert atmosphere;

Reference yield:

4-Phenyl-2-Thiazolecarboxaldehyde (75390-44-2) → 2-hydroxymethyl-4-phenylthiazole (65384-99-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol;

upstream raw materials:

2-ethoxymethyl-4-phenyl-thiazole

(4-phenylthiazol-2-yl)methyl benzoate

α-bromoacetophenone

4-Phenyl-2-Thiazolecarboxaldehyde

Downstream raw materials:

4-Phenyl-2-Thiazolecarboxaldehyde

2-chloromethyl-4-phenylthiazole

2-(bromomethyl)-4-phenylthiazole

[4-Oxo-3-(4-phenyl-thiazol-2-ylmethyl)-3,4-dihydro-phthalazin-1-yl]-acetic acid