tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Base Information

Chemical Name:tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane
CAS No.:400054-08-2
Molecular Formula:C₂₀H₂₉NO₅Si
Molecular Weight:391.539
Hs Code.:

<i>tert</i>-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2<i>H</i>-pyran-2-ylmethoxy]-dimethyl-silane

Synonyms:tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

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Chemical Property of tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

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Technology Process of tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

There total 7 articles about tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 755011-68-8
carbamic acid 6-(tert-butyl-dimethyl-silanyloxymethyl)-2-(4-methoxy-phenoxy)-3,6-dihydro-2H-pyran-3-yl ester

: 400054-08-2
tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Guidance literature:: With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane; at -40 - 0 ℃; for 0.5h;
DOI:10.1002/chem.200305358

Reference yield:

: 83-87-4,604-68-2,604-69-3,2152-77-4,4026-35-1,4163-59-1,4163-60-4,4163-61-5,4163-65-9,4257-94-7,4257-96-9,16299-15-3,19186-39-1,19189-55-0,25878-60-8,25941-03-1,32445-48-0,32445-49-1,32445-53-7,32445-54-8,34685-58-0,34685-59-1,43168-42-9,43168-44-1,43169-22-8,43169-25-1,66966-07-2,70749-17-6,80184-01-6,93221-01-3,93221-02-4,99630-88-3,109215-53-4,115792-70-6,115792-73-9,139894-92-1,139973-25-4,144071-49-8,147648-81-5
D-glucose pentaacetate

: 400054-08-2
tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1.1: 974.8 g / PBr₃; H₂O / 96 h / 20 °C

2.1: 57 percent / DBU / dimethylformamide / 1 h / -10 °C

3.1: 49 percent / BF₃*OEt₂ / benzene / 20 °C

4.1: 84 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

5.1: 75 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

6.1: CH₂Cl₂ / 1 h / 0 °C

6.2: 25.6 g / aq. K₂CO₃ / methanol / 2.5 h / 20 °C

7.1: CBr₄; PPh₃; Et₃N / CH₂Cl₂ / 0.5 h / -40 - 0 °C

With dmap; lithium aluminium tetrahydride; carbon tetrabromide; boron trifluoride diethyl etherate; water; phosphorus tribromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1002/chem.200305358

Reference yield:

: 400054-06-0
p-methoxyphenyl 6-O-(tert-butyldimethylsilyl)-3,4-dideoxy-α-D-erythro-hex-3-enopyranoside

: 400054-08-2
tert-butyl-[5-cyanato-6-(4-methoxy-phenoxy)-5,6-dihydro-2H-pyran-2-ylmethoxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: CH₂Cl₂ / 1 h / 0 °C

1.2: 25.6 g / aq. K₂CO₃ / methanol / 2.5 h / 20 °C

2.1: CBr₄; PPh₃; Et₃N / CH₂Cl₂ / 0.5 h / -40 - 0 °C

With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane;
DOI:10.1002/chem.200305358