tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate
CAS No.:1315336-72-1
Molecular Formula:C₂₃H₂₆N₆O₅
Molecular Weight:466.497
Hs Code.:

Synonyms:tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

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Chemical Property of tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

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Technology Process of tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

There total 8 articles about tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 79-14-1
glycolic Acid

: 1315336-71-0
tert-butyl (4-(2-(2-(allyloxy)-4-aminophenyl)-2H-tetrazol-5-yl)phenyl)carbamate

: 1315336-72-1
tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ja204758c

Reference yield:

: 1315336-70-9
tert-butyl (4-(2-(2-(allyloxy)-4-(2,2,2-trifluoroacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

: 1315336-72-1
tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol; water; sodium methylate / 50 °C

2: 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C

With methanol; 1-hydroxy-7-aza-benzotriazole; water; sodium methylate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/ja204758c

Reference yield:

: 351188-76-6
(E)-methyl 4-((2-(phenylsulfonyl)hydrazono)methyl)benzoate

: 1315336-72-1
tert-butyl (4-(2-(2-(allyloxy)-4-(2-hydroxyacetamido)phenyl)-2H-tetrazol-5-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / -20 °C

2: ethanol; water; iron; acetic acid / Sonication

3: lithium hydroxide monohydrate / tetrahydrofuran / 20 °C

4: triethylamine / tetrahydrofuran; dichloromethane / 20 °C

5: diphenyl phosphoryl azide; triethylamine / toluene / Molecular sieve; Inert atmosphere; Reflux

6: methanol; water; sodium methylate / 50 °C

7: 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C

With pyridine; methanol; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; ethanol; diphenyl phosphoryl azide; water; sodium methylate; iron; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja204758c