di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate

Base Information

Chemical Name:di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate
CAS No.:1407506-16-4
Molecular Formula:C₃₄H₄₉NO₁₀S
Molecular Weight:663.83
Hs Code.:

Synonyms:di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate

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Chemical Property of di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate

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Technology Process of di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate

There total 4 articles about di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.1%

: 1309452-61-6
di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-(4-hydroxybenzyl)-L-glutamate

: 6315-52-2
1,2-bis-tosyloxyethane

: 1407506-16-4
di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 5544-60-5
4-(benzyloxy)benzyl bromide

: 1407506-16-4
di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -70 °C

1.2: 2 h / -70 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With hydrogen; caesium carbonate; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: di-tert-butyl (N-tert-butoxycarbonyl)-L-glutamate

: 1407506-16-4
di-tert-butyl (4S)-N-(tert-butoxycarbonyl)-4-{4-[2-(tosyloxy)ethoxy]benzyl}-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3.5 h / -70 °C

1.2: 2 h / -70 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With hydrogen; caesium carbonate; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;