C₁₁H₁₅BrO₄

Base Information

• Chemical Name: C₁₁H₁₅BrO₄
• CAS No.: 1037310-93-2
• Molecular Formula: C₁₁H₁₅BrO₄
• Molecular Weight: 291.142
• Mol file: 1037310-93-2.mol

Synonyms:C₁₁H₁₅BrO₄

Chemical Property of C₁₁H₁₅BrO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₁H₁₅BrO₄

There total 1 articles about C₁₁H₁₅BrO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,6-dibromocyclohex-1-ene (17202-32-3) + malonic acid dimethyl ester (108-59-8) → C11H15BrO4 (1037310-93-2)

Guidance literature:

malonic acid dimethyl ester; With sodium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 0.25h; Inert atmosphere; Schlenk technique;

1,6-dibromocyclohex-1-ene; In 1,2-dimethoxyethane; at 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules19056058

Reference yield: 74.0%

C11H15BrO4 (1037310-93-2) + propargyl bromide (106-96-7) → dimethyl 2-(2-bromocyclohex-2-enyl)-2-prop-2-ynyl-malonate (1637587-02-0)

Guidance literature:

C₁₁H₁₅BrO₄; With sodium hydride; In 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

propargyl bromide; In 1,2-dimethoxyethane; mineral oil; at 0 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules19056058

Reference yield:

C11H15BrO4 (1037310-93-2) → dimethyl 2-(2-bromocyclohex-2-enyl)-2-[3-(t-butyldimethylsilanyl)prop-2-ynyl]malonate (1637587-03-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; 1,2-dimethoxyethane / 0.5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

1.2: 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere; Schlenk technique

2.2: 4 h / 20 °C / Inert atmosphere; Schlenk technique

With n-butyllithium; sodium hydride; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; mineral oil;

DOI:10.3390/molecules19056058

upstream raw materials:

1,6-dibromocyclohex-1-ene

malonic acid dimethyl ester

Downstream raw materials:

dimethyl 2-(2-bromocyclohex-2-enyl)-2-prop-2-ynyl-malonate

dimethyl 2-(2-bromocyclohex-2-enyl)-2-[3-(t-butyldimethylsilanyl)prop-2-ynyl]malonate