(S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride

Base Information

Chemical Name:(S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride
CAS No.:1093191-42-4
Molecular Formula:C₂₈H₃₃N₃O₄*ClH
Molecular Weight:512.049
Hs Code.:

Synonyms:(S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride

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Chemical Property of (S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride

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Technology Process of (S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride

There total 5 articles about (S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1093191-41-3
4-((S)-carboxy-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)methyl)piperidine-1-carboxylic acid tert-butyl ester

: 77-76-9
2,2-dimethoxy-propane

: 1093191-42-4
(S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In water; at 60 ℃; for 3h;

Reference yield:

: 3032-92-6
4-cyanophenylacetylene

: 1093191-42-4
(S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C

2.1: sodium tris(acetoxy)borohydride / chloroform / 4 h / 20 °C

3.1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 130 °C / Microwave irradiation

3.2: pH ~ 3

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.1: N,O-bis-(trimethylsilyl)-acetamide / 1,4-dioxane / 0.17 h / 100 °C

5.2: 20 °C

6.1: hydrogenchloride / water / 3 h / 60 °C

With hydrogenchloride; lithium hydroxide; copper(l) iodide; N,O-bis-(trimethylsilyl)-acetamide; water; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1093191-42-4
(S)-(4-(4-morpholin-4-ylmethylphenylethynyl)benzoylamino)piperidin-4-ylacetix acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C

2.1: sodium tris(acetoxy)borohydride / chloroform / 4 h / 20 °C

3.1: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 130 °C / Microwave irradiation

3.2: pH ~ 3

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.1: N,O-bis-(trimethylsilyl)-acetamide / 1,4-dioxane / 0.17 h / 100 °C

5.2: 20 °C

6.1: hydrogenchloride / water / 3 h / 60 °C

With hydrogenchloride; lithium hydroxide; copper(l) iodide; N,O-bis-(trimethylsilyl)-acetamide; water; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;