(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline

Base Information

• Chemical Name: (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline
• CAS No.: 1434175-74-2
• Molecular Formula: C₃₇H₅₅N₃O₄Sn
• Molecular Weight: 724.571
• Mol file: 1434175-74-2.mol

Synonyms:(E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline

Chemical Property of (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline

There total 4 articles about (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(E)-4-[2-(6-bromo-1-tert-butoxycarbonylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline (1434175-72-0) + bis(tri-n-butyltin) (813-19-4) → (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline (1434175-74-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; triethylamine; for 5h; Reflux;

DOI:10.1016/j.bmc.2013.02.054

Reference yield:

4-Bromo-benzene-1,2-diamine (1575-37-7) → (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline (1434175-74-2)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium metabisulfite / N,N-dimethyl-formamide / 2 h / 105 °C

2: hydrogenchloride; iron / ethanol; water / 24 h / Reflux

3: guanidine hydrochloride / ethanol / 2 h / 40 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; triethylamine / 5 h / Reflux

With hydrogenchloride; sodium metabisulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; guanidine hydrochloride; iron; In 1,4-dioxane; ethanol; water; triethylamine; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.02.054

Reference yield:

(E)-6-bromo-2-(4-nitrostyryl)-1H-benzimidazole (1434175-67-3) → (E)-4-[2-(1-tert-butoxycarbonyl-6-tributylstannylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline (1434175-74-2)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride; iron / ethanol; water / 24 h / Reflux

2: guanidine hydrochloride / ethanol / 2 h / 40 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; triethylamine / 5 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; guanidine hydrochloride; iron; In 1,4-dioxane; ethanol; water; triethylamine;

DOI:10.1016/j.bmc.2013.02.054

upstream raw materials:

(E)-6-bromo-2-(4-nitrostyryl)-1H-benzimidazole

4-Bromo-benzene-1,2-diamine

(E)-4-[2-(6-bromo-1-tert-butoxycarbonylbenzimidazol-2-yl)ethenyl]-N-tert-butoxycarbonylaniline

bis(tri-n-butyltin)

Downstream raw materials:

C₁₅H₁₂⁽¹²⁵⁾IN₃