methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride

Base Information

Chemical Name:methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride
CAS No.:106787-81-9
Molecular Formula:C₁₇H₁₅NO₄*ClH
Molecular Weight:333.771
Hs Code.:

Synonyms:methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride

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Chemical Property of methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride

Chemical Property:

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Technology Process of methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride

There total 6 articles about methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40611-00-5
DL-3-(3,4-dihydroxyphenyl)alanine methyl ester hydrochloride

: 106787-81-9
methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 20 h / Ambient temperature

2: Lawesson's reagent / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

3: 10 percent anhydrous HCl / methanol / 1 h / Ambient temperature

4: 1.) 4-nitrobenzyl bromide; 2.) pyridine / 1.) BuCN, 115 deg C, 60 h; 2.) RT, 2 h

5: HCl, CH₃OH

With Lawessons reagent; pyridine; hydrogenchloride; methanol; 1-bromomethyl-4-nitro-benzene; In methanol; 1,2-dimethoxyethane;
DOI:10.1248/cpb.34.1994

Reference yield:

: 93-97-0
benzoic acid anhydride

: 106787-81-9
methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 20 h / Ambient temperature

2: Lawesson's reagent / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

3: 10 percent anhydrous HCl / methanol / 1 h / Ambient temperature

4: 1.) 4-nitrobenzyl bromide; 2.) pyridine / 1.) BuCN, 115 deg C, 60 h; 2.) RT, 2 h

5: HCl, CH₃OH

With Lawessons reagent; pyridine; hydrogenchloride; methanol; 1-bromomethyl-4-nitro-benzene; In methanol; 1,2-dimethoxyethane;
DOI:10.1248/cpb.34.1994

Reference yield:

: 35091-14-6
Methyl N-benzoyl-3',4'bis(benzoyloxy)phenylalaninate

: 106787-81-9
methyl 6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-3-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: Lawesson's reagent / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

2: 10 percent anhydrous HCl / methanol / 1 h / Ambient temperature

3: 1.) 4-nitrobenzyl bromide; 2.) pyridine / 1.) BuCN, 115 deg C, 60 h; 2.) RT, 2 h

4: HCl, CH₃OH

With Lawessons reagent; pyridine; hydrogenchloride; methanol; 1-bromomethyl-4-nitro-benzene; In methanol; 1,2-dimethoxyethane;
DOI:10.1248/cpb.34.1994