2-benzoylhept-5-ynoic acid ethyl ester

Base Information

• Chemical Name: 2-benzoylhept-5-ynoic acid ethyl ester
• CAS No.: 811784-44-8
• Molecular Formula: C₁₆H₁₈O₃
• Molecular Weight: 258.317
• Mol file: 811784-44-8.mol

Synonyms:2-benzoylhept-5-ynoic acid ethyl ester

Chemical Property of 2-benzoylhept-5-ynoic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-benzoylhept-5-ynoic acid ethyl ester

There total 1 articles about 2-benzoylhept-5-ynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) + methanesulfonic acid pent-3-ynyl ester (106060-18-8) → 2-benzoylhept-5-ynoic acid ethyl ester (811784-44-8)

Guidance literature:

ethyl 3-oxo-3-phenylpropionate; With sodium hydride; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;

methanesulfonic acid pent-3-ynyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at 95 ℃; for 8h;

DOI:10.1002/anie.200460844

Reference yield: 91.0%

2-benzoylhept-5-ynoic acid ethyl ester (811784-44-8) → 1-benzoyl-2-methyl-cyclopent-2-enecarboxylic acid ethyl ester

Guidance literature:

With zinc diacetate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); scandium tris(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 72h; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.201201060

Reference yield: 70.0%

2-benzoylhept-5-ynoic acid ethyl ester (811784-44-8) → (S)-1-benzoyl-2-methyl-cyclopent-2-enecarboxylic acid ethyl ester (1378930-63-2)

Guidance literature:

With zinc diacetate; (S,S)-2,2'-isopropylidenebis(4-phenyl-2-oxazoline); ytterbium(III) triflate; In dichloromethane; at 0 ℃; for 60h; optical yield given as %ee; Inert atmosphere; Molecular sieve;

DOI:10.1002/anie.201201060

upstream raw materials:

ethyl 3-oxo-3-phenylpropionate

methanesulfonic acid pent-3-ynyl ester

Downstream raw materials:

(S)-1-benzoyl-2-methyl-cyclopent-2-enecarboxylic acid ethyl ester