(2S)-2-hydroxy-2-phenylhexanoic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

Base Information

Chemical Name:(2S)-2-hydroxy-2-phenylhexanoic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester
CAS No.:1154062-12-0
Molecular Formula:C₃₂H₄₀O₆
Molecular Weight:520.666
Hs Code.:

Synonyms:(2S)-2-hydroxy-2-phenylhexanoic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

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Chemical Property of (2S)-2-hydroxy-2-phenylhexanoic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

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Technology Process of (2S)-2-hydroxy-2-phenylhexanoic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

There total 1 articles about (2S)-2-hydroxy-2-phenylhexanoic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 916525-76-3
oxophenylacetic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

: 693-04-9
butyl magnesium bromide

: 1154062-12-0
(2S)-2-hydroxy-2-phenylhexanoic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester

Guidance literature:: butyl magnesium bromide; With zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 2h; Inert atmosphere;

oxophenylacetic acid (1R,2S)-1,2-bis(2-methoxyphenyl)-2-(2-methylpropoxy)ethyl ester; In tetrahydrofuran; diethyl ether; at -90 - -78 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 0.25h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tetasy.2009.02.004