(2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane

Base Information

• Chemical Name: (2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane
• CAS No.: 1200143-64-1
• Molecular Formula: C₁₆H₂₄O₅
• Molecular Weight: 296.364
• Mol file: 1200143-64-1.mol

Synonyms:(2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane

Chemical Property of (2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane

There total 1 articles about (2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane (1200143-77-6) → (2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane (1200143-64-1)

Guidance literature:

With (acetao)(aqua)(S,S)-N,N′-bis(3,5-di-tert-butylsalicylidene-1,2-cyclohexanediamino)-cobalt(III); acetic acid; In toluene; at 20 ℃; for 1h; optical yield given as %ee;

DOI:10.1055/s-0029-1216953

Reference yield: 85.0%

(2S)-2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane (1200143-64-1) + vinyl magnesium bromide (1826-67-1) → (4R,6S)-6-(methoxymethoxy)-8-[4-(methoxymethoxy)phenyl]oct-1-en-4-ol (1200143-70-9)

Guidance literature:

With copper(l) iodide; In dichloromethane; at -10 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0029-1216953

upstream raw materials:

2-{(2S)-2-(methoxymethoxy)-4-[4-(methoxymethoxy)phenyl]butyl}oxirane

Downstream raw materials:

(4R,6S)-6-(methoxymethoxy)-8-[4-(methoxymethoxy)phenyl]oct-1-en-4-ol