Bz-Ile-Glu(O-2-Ada)-Gly-OBzl

Base Information

• Chemical Name: Bz-Ile-Glu(O-2-Ada)-Gly-OBzl
• CAS No.: 177897-83-5
• Molecular Formula: C₃₇H₄₇N₃O₇
• Molecular Weight: 645.796
• Mol file: 177897-83-5.mol

Synonyms:Bz-Ile-Glu(O-2-Ada)-Gly-OBzl

Chemical Property of Bz-Ile-Glu(O-2-Ada)-Gly-OBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Bz-Ile-Glu(O-2-Ada)-Gly-OBzl

There total 1 articles about Bz-Ile-Glu(O-2-Ada)-Gly-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

benzoyl chloride (98-88-4) + H-Ile-Glu(O-2-Ada)-Gly-OBzl trifluoroacetate → Bz-Ile-Glu(O-2-Ada)-Gly-OBzl (177897-83-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1248/cpb.45.88

Reference yield: 77.1%

Bz-Ile-Glu(O-2-Ada)-Gly-OBzl (177897-83-5) → Bz-Ile-Glu(O-2-Ada)-Gly-OH (177897-85-7)

Guidance literature:

With hydrogen; palladium; In methanol; for 6h;

DOI:10.1248/cpb.45.88

Reference yield:

Bz-Ile-Glu(O-2-Ada)-Gly-OBzl (177897-83-5) → (S)-4-((2S,3S)-2-Benzoylamino-3-methyl-pentanoylamino)-4-(2-isobutoxycarbonyloxy-2-oxo-ethylcarbamoyl)-butyric acid adamantan-2-yl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 77.1 percent / H₂ / Pd / methanol / 6 h

2: Et₃N

With hydrogen; triethylamine; palladium; In methanol;

DOI:10.1248/cpb.45.88

upstream raw materials:

benzoyl chloride

Downstream raw materials:

Bz-Ile-Glu(O-2-Ada)-Gly-OH

Bz-Ile-Glu(O-2-Ada)-Gly-Arg(Mts)-CH₂Cl