(4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol

Base Information

Chemical Name:(4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol
CAS No.:874126-56-4
Molecular Formula:C₃₁H₂₇IO₄
Molecular Weight:590.457
Hs Code.:

Synonyms:(4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol

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Chemical Property of (4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol

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Technology Process of (4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol

There total 5 articles about (4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 874126-54-2
4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-benzaldehyde

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 874126-56-4
(4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol

Guidance literature:: In tetrahydrofuran; at -40 ℃;
DOI:10.1016/j.tetlet.2005.10.110

Reference yield:

: 874126-48-4
(4-iodophenyl)(4-methoxyphenyl)methanol

: 874126-56-4
(4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaH / tetrahydrofuran; dimethylformamide / 20 °C

2: 73 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 60 °C

3: 89 percent / tetrahydrofuran / -40 °C

With copper(l) iodide; sodium hydride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Williamson alkylation / 2: Sonogashira-Linstrumelle coupling / 3: Grignard addition;
DOI:10.1016/j.tetlet.2005.10.110

Reference yield:

: 874126-50-8
C₁₇H₁₅IO₂

: 874126-56-4
(4-{3-[(4-iodo-phenyl)-(4-methoxy-phenyl)-methoxy]-prop-1-ynyl}-phenyl)-(4-methoxy-phenyl)-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / CuI; Et₃N / PdCl₂(PPh₃)2 / 60 °C

2: 89 percent / tetrahydrofuran / -40 °C

With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1: Sonogashira-Linstrumelle coupling / 2: Grignard addition;
DOI:10.1016/j.tetlet.2005.10.110