5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

Base Information

Chemical Name:5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide
CAS No.:1355064-61-7
Molecular Formula:C₁₆H₁₂Cl₂F₃N₃O₄S
Molecular Weight:470.256
Hs Code.:

Synonyms:5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

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Chemical Property of 5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

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Technology Process of 5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

There total 2 articles about 5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 288315-03-7
3,3-difluoroazetidine hydrochloride

: 1355063-64-7
5-chloro-4-[(5-chloro-6-fluoropyridin-3-yl)oxy]-2-fluoro-N-(methylsulfonyl)benzamide

: 1355064-61-7
5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 15h; microwave irradiation;

Reference yield:

: 1355069-01-0
5-Chloro-4-(5-chloro-6-fluoropyridin-3-yloxy)-2-fluorobenzoic acid

: 1355064-61-7
5-Chloro-4-(5-chloro-6-(3,3-difluoroazetidin-1-yl)pyridin-3-yloxy)-2-fluoro-N-(methylsulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 15 h / 90 °C / microwave irradiation

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; dimethyl sulfoxide;