(5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one

Base Information

• Chemical Name: (5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one
• CAS No.: 1312022-94-8
• Molecular Formula: C₁₉H₂₆N₂O₂
• Molecular Weight: 314.428
• Mol file: 1312022-94-8.mol

Synonyms:(5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one

Chemical Property of (5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one

There total 5 articles about (5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

propargyl bromide (106-96-7) + (5S)-3-butyl-5-[(4-hydroxyphenyl)methyl]-2,2-dimethylimidazolidin-4-one (469873-54-9) → (5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one (1312022-94-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201100072

Reference yield:

(2S)-2-amino-N-butyl-3-(4-hydroxyphenyl)propanamide (40829-19-4) → (5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one (1312022-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / methanol / 24 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/chem.201100072

Reference yield:

L-tyrosine methyl ester HCl (3417-91-2) → (5S)-3-butyl-2,2-dimethyl-5-{[4-(prop-2-yn-1-yloxy)phenyl]methyl}imidazolidin-4-one (1312022-94-8)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 48 h / 20 °C

2: toluene-4-sulfonic acid / methanol / 24 h / Reflux

3: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With sodium hydride; toluene-4-sulfonic acid; In methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1002/chem.201100072

upstream raw materials:

L-tyrosine methyl ester HCl

L-tyrosine

propargyl bromide

(5S)-3-butyl-5-[(4-hydroxyphenyl)methyl]-2,2-dimethylimidazolidin-4-one

Downstream raw materials:

C₂₅H₄₁N₅O₅Si

C₂₈H₃₅N₅O₂