2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)

Base Information

Chemical Name:2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)
CAS No.:1380450-18-9
Molecular Formula:C₄₂H₂₉BrO₃
Molecular Weight:661.594
Hs Code.:

Synonyms:2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)

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Chemical Property of 2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)

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Technology Process of 2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)

There total 7 articles about 2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1276030-81-9
1-iodo-2-((4-methoxyphenyl)ethynyl)benzene

: 1380450-05-4
1-(2-bromoethoxy)-2,3-diethynylbenzene

: 1380450-18-9
2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; for 8h;
DOI:10.1021/ja3023626

Reference yield:

: 408340-16-9
2,3-diiodophenol

: 1380450-18-9
2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)

Guidance literature:: Multi-step reaction with 4 steps

1.1: 18-crown-6 ether; potassium carbonate / acetone / Reflux

1.2: Reflux

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h

3.1: potassium carbonate / tetrahydrofuran; methanol / 8 h / 20 °C / Inert atmosphere

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 18-crown-6 ether; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; acetone; 2.1: Sonogashira coupling / 4.1: Sonogashira coupling;
DOI:10.1021/ja3023626

Reference yield:

: 863870-82-0
O-2,3-diiodophenyl N,N-diethylcarbamate

: 1380450-18-9
2,2'-((3-(2-bromoethoxy)-1,2-phenylene)bis(ethyne-2,1-diyl))bis(((4-methoxyphenyl)ethynyl)benzene)

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / ethanol / 8 h / Reflux

2.1: 18-crown-6 ether; potassium carbonate / acetone / Reflux

2.2: Reflux

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h

4.1: potassium carbonate / tetrahydrofuran; methanol / 8 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 8 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 18-crown-6 ether; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; acetone; 3.1: Sonogashira coupling / 5.1: Sonogashira coupling;
DOI:10.1021/ja3023626